Molecular and Clinical Links between Drug-Induced Cholestasis and Familial Intrahepatic Cholestasis.
ABCB1
ABCB11
ABCB4
ABCC2
BSEP protein
MDR1 protein
MDR3 protein
MRP2
drug-induced cholestasis
familial intrahepatic cholestasis
idiosyncratic drug-induced liver injury
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Mar 2023
18 Mar 2023
Historique:
received:
16
02
2023
revised:
11
03
2023
accepted:
14
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
Idiosyncratic Drug-Induced Liver Injury (iDILI) represents an actual health challenge, accounting for more than 40% of hepatitis cases in adults over 50 years and more than 50% of acute fulminant hepatic failure cases. In addition, approximately 30% of iDILI are cholestatic (drug-induced cholestasis (DIC)). The liver's metabolism and clearance of lipophilic drugs depend on their emission into the bile. Therefore, many medications cause cholestasis through their interaction with hepatic transporters. The main canalicular efflux transport proteins include: 1. the bile salt export pump (BSEP) protein (
Identifiants
pubmed: 36982896
pii: ijms24065823
doi: 10.3390/ijms24065823
pmc: PMC10057459
pii:
doi:
Substances chimiques
Bile Acids and Salts
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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