S100B Protein but Not 3-Nitrotyrosine Positively Correlates with Plasma Ammonia in Patients with Inherited Hyperammonemias: A New Promising Diagnostic Tool?

3-nitrotyrosine S100B ammonia urea cycle disorders

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
21 Mar 2023
Historique:
received: 24 02 2023
revised: 15 03 2023
accepted: 17 03 2023
medline: 30 3 2023
entrez: 29 3 2023
pubmed: 30 3 2023
Statut: epublish

Résumé

Individuals with inherited hyperammonemias often present developmental and intellectual deficiencies which are likely to be exaggerated by hyperammonemia episodes in long-term outcomes. In order to find a new, systemic marker common to the course of congenital hyperammonemias, we decided to measure the plasma level of S100 calcium-binding protein B (S100B), which is associated with cerebral impairment. Further, we analyzed three mechanistically diverged but linked with oxidative-nitrosative stress biochemical parameters: 3-nitrotyrosine (3-NT), a measure of plasma proteins' nitration; advanced oxidation protein products (AOPP), a measure of protein oxidation; and glutathione peroxidase (GPx) activity, a measure of anti-oxidative enzymatic capacity. The plasma biomarkers listed above were determined for the first time in congenital hyperammonemia. Also, the level of pro- and anti-inflammatory mediators (i.e., IL-12, IL-6, IL-8, TNF-α, IL-1β, and IL-10) and chemokines (IP-10, MCP-1, MIG, and RANTES) were quantified. S100B was positively correlated with plasma ammonia level, while noticeable levels of circulating 3-NT in some of the patients' plasma did not correlate with ammonia concentration. Overall, the linear correlation between ammonia and S100B but not standard oxidative stress-related markers offers a unique perspective for the future identification and monitoring of neurological deficits risk-linked with hyperammonemia episodes in patients with inherited hyperammonemias. The S100B measure may support the development of therapeutic targets and clinical monitoring in these disorders.

Identifiants

pubmed: 36983411
pii: jcm12062411
doi: 10.3390/jcm12062411
pmc: PMC10056255
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : 1)Internal grant of The Children's Memorial Health Institute 2) Statutory MMRI funds
ID : 1) S174/2018 2) 13

Références

Mol Genet Metab. 2004 Apr;81 Suppl 1:S58-62
pubmed: 15050975
Psychiatry Res. 2016 May 30;239:85-91
pubmed: 27137966
J Physiol Biochem. 2003 Dec;59(4):255-61
pubmed: 15164944
J Neuroimmunol. 2007 Mar;184(1-2):214-22
pubmed: 17254641
Kidney Int. 1996 May;49(5):1304-13
pubmed: 8731095
J Nephrol. 2002 Jul-Aug;15(4):336-41
pubmed: 12243361
Clin Biochem. 2008 Jul;41(10-11):755-63
pubmed: 18454941
J Exp Med. 2015 Jun 29;212(7):991-9
pubmed: 26077718
PLoS One. 2010 Sep 10;5(9):
pubmed: 20844757
J Inherit Metab Dis. 2016 Sep;39(5):661-672
pubmed: 27106216
East Mediterr Health J. 2007 Sep-Oct;13(5):1114-23
pubmed: 18290405
Free Radic Res. 2021 Jun;55(6):627-640
pubmed: 33504220
Clin Chem. 2003 Jun;49(6 Pt 1):997-9
pubmed: 12766011
BMC Neurol. 2009 Oct 08;9:51
pubmed: 19814795
Ann Neurol. 2019 Jul;86(1):116-128
pubmed: 31018246
Clin Chem. 2014 Jun;60(6):823-34
pubmed: 24170612
BMJ Open. 2019 May 24;9(5):e027365
pubmed: 31129587
Liver Int. 2013 Nov;33(10):1478-89
pubmed: 23714168
Nat Rev Dis Primers. 2022 Jun 23;8(1):43
pubmed: 35739133
Front Biosci. 2002 May 01;7:d1356-68
pubmed: 11991838
J Inherit Metab Dis. 2019 Mar;42(2):243-253
pubmed: 30671983
GE Port J Gastroenterol. 2020 Nov;27(6):391-403
pubmed: 33251288
Curr Neuropharmacol. 2014 Mar;12(2):168-85
pubmed: 24669210
Clin Chem Lab Med. 2016 May;54(5):833-42
pubmed: 26479347
Biochim Biophys Acta Mol Basis Dis. 2019 Aug 1;1865(8):1949-1967
pubmed: 30500433
Brain Res Dev Brain Res. 2000 Feb 7;119(2):159-68
pubmed: 10675765
J Immunol. 2006 May 1;176(9):5587-97
pubmed: 16622028
Am J Gastroenterol. 2011 Sep;106(9):1629-37
pubmed: 21483460
J Biol Chem. 2005 Jun 3;280(22):20937-44
pubmed: 15802262
Metab Brain Dis. 2007 Mar;22(1):125-38
pubmed: 17260161
Neurosurg Focus. 2010 Nov;29(5):E2
pubmed: 21039136
CMAJ. 2017 Mar 13;189(10):E384-E390
pubmed: 27895145
Sci Transl Med. 2012 Aug 15;4(147):147ra111
pubmed: 22896675
Arch Biochem Biophys. 2013 Aug 15;536(2):101-8
pubmed: 23628343
Eur J Pediatr. 2003 Jun;162(6):410-6
pubmed: 12684900
Microsc Res Tech. 2003 Apr 15;60(6):614-32
pubmed: 12645009
Nature. 1993 Aug 12;364(6438):626-32
pubmed: 8394509
Mol Genet Metab. 2009 Sep-Oct;98(1-2):173-80
pubmed: 19604711
J Biol Chem. 2011 Mar 4;286(9):7214-26
pubmed: 21209080
Hepat Med. 2018 Sep 12;10:105-115
pubmed: 30254497
Mol Genet Metab. 2004 Apr;81 Suppl 1:S86-91
pubmed: 15050980
Pediatr Crit Care Med. 2004 Jan;5(1):53-7
pubmed: 14697109
BMC Neurosci. 2007 Jan 02;8:2
pubmed: 17199889
Am J Cardiol. 2009 Jul 1;104(1):92-6
pubmed: 19576326
Brain Behav Immun. 2018 May;70:61-75
pubmed: 29499302
J Neurochem. 2019 Jan;148(2):168-187
pubmed: 30144068
Am J Med. 2003 Feb 15;114(3):188-93
pubmed: 12637132
J Intensive Care. 2014 Mar 13;2(1):22
pubmed: 25908985
Liver Transpl. 2003 Aug;9(8):887-8
pubmed: 12884207
Int Rev Neurobiol. 2004;59:445-70
pubmed: 15006498
J Neurosci. 2015 Jan 14;35(2):518-26
pubmed: 25589747
Hepatology. 2019 Sep;70(3):982-994
pubmed: 30703853
Liver Int. 2008 Jan;28(1):146-7
pubmed: 18173564
Antioxid Redox Signal. 2019 Mar 20;30(9):1162-1185
pubmed: 29482336
Metabolism. 1989 Aug;38(8 Suppl 1):14-7
pubmed: 2569662
Transl Gastroenterol Hepatol. 2021 Jan 05;6:8
pubmed: 33409402
Biochim Biophys Acta. 1983 Jan 25;755(2):272-8
pubmed: 6131695
World J Gastroenterol. 2016 May 7;22(17):4397-402
pubmed: 27158209
Clin Chem. 2002 Jun;48(6 Pt 1):950-2
pubmed: 12029017
Brain Res Bull. 2006 Jun 30;70(2):179-85
pubmed: 16782507
J Pediatr Gastroenterol Nutr. 2019 Jul;69(1):108-115
pubmed: 31058776
Brain Res. 1979 Feb 2;161(2):303-10
pubmed: 31966
Int J Mol Sci. 2013 Feb 05;14(2):3265-84
pubmed: 23385234
Liver Transpl. 2001 Nov;7(11):964-70
pubmed: 11699032
Osteoarthritis Cartilage. 2013 Jan;21(1):151-6
pubmed: 23025928
J Inherit Metab Dis. 2019 Nov;42(6):1192-1230
pubmed: 30982989
Crit Care Clin. 2005 Oct;21(4 Suppl):S9-17
pubmed: 16227115
Eur J Pediatr. 2011 Jan;170(1):21-34
pubmed: 21165747

Auteurs

Anna Maria Czarnecka (AM)

Department of Neurotoxicology, Mossakowski Medical Research Institute Polish Academy of Sciences, Pawińskiego 5, 02-106 Warsaw, Poland.

Marta Obara-Michlewska (M)

Department of Neurotoxicology, Mossakowski Medical Research Institute Polish Academy of Sciences, Pawińskiego 5, 02-106 Warsaw, Poland.

Dorota Wesół-Kucharska (D)

Department of Pediatrics, Nutrition, and Metabolic Diseases, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland.

Milena Greczan (M)

Department of Pediatrics, Nutrition, and Metabolic Diseases, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland.

Magdalena Kaczor (M)

Department of Pediatrics, Nutrition, and Metabolic Diseases, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland.

Janusz Książyk (J)

Department of Pediatrics, Nutrition, and Metabolic Diseases, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland.

Dariusz Rokicki (D)

Department of Pediatrics, Nutrition, and Metabolic Diseases, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland.

Magdalena Zielińska (M)

Department of Neurotoxicology, Mossakowski Medical Research Institute Polish Academy of Sciences, Pawińskiego 5, 02-106 Warsaw, Poland.

Classifications MeSH