Structural and Functional Characterization of the Newly Designed Antimicrobial Peptide Crabrolin21.
CD spectroscopy
NMR spectroscopy
antimicrobial resistance
membrane specificity
Journal
Membranes
ISSN: 2077-0375
Titre abrégé: Membranes (Basel)
Pays: Switzerland
ID NLM: 101577807
Informations de publication
Date de publication:
22 Mar 2023
22 Mar 2023
Historique:
received:
02
02
2023
revised:
16
03
2023
accepted:
17
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
(1) Background: antimicrobial resistance is becoming a dramatic problem for public health, and the design of new antimicrobial agents is an active research area. (2) Methods: based on our previous work, we designed an improved version of the crabrolin peptide and characterized its functional and structural properties with a wide range of techniques. (3) Results: the newly designed peptide, crabrolin21, is much more active than the previous ones and shows specific selectivity towards bacterial cells. (4) Conclusions: crabrolin21 shows interesting properties and deserves further studies.
Identifiants
pubmed: 36984752
pii: membranes13030365
doi: 10.3390/membranes13030365
pmc: PMC10053045
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : iNEXT-Discovery in Horizon 2020
ID : 871037
Organisme : Italian Ministry of University and Research
ID : PRIN project 2020833Y75
Organisme : Regione Lazio
ID : Contributo premiale per i ricercatori 2022', DE G05411
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