The Gut Microbiome of an Indigenous Agropastoralist Population in a Remote Area of Colombia with High Rates of Gastrointestinal Infections and Dysbiosis.
Colombia
Indigenous
dysbiosis
gastroenteritis
gut microbiome
next generation sequencing
remote tropical area
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
28 Feb 2023
28 Feb 2023
Historique:
received:
25
01
2023
revised:
20
02
2023
accepted:
21
02
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
An Indigenous agropastoralist population called the Wiwa from the Sierra Nevada de Santa Marta, in North-East Colombia, shows high rates of gastrointestinal infections. Chronic gut inflammatory processes and dysbiosis could be a reason, suggesting an influence or predisposing potential of the gut microbiome composition. The latter was analyzed by 16S rRNA gene amplicon next generation sequencing from stool samples. Results of the Wiwa population microbiomes were associated with available epidemiological and morphometric data and compared to control samples from a local urban population. Indeed, locational-, age-, and gender-specific differences in the Firmicutes/Bacteriodetes ratio, core microbiome, and overall genera-level microbiome composition were shown. Alpha- and ß-diversity separated the urban site from the Indigenous locations. Urban microbiomes were dominated by
Identifiants
pubmed: 36985199
pii: microorganisms11030625
doi: 10.3390/microorganisms11030625
pmc: PMC10052337
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : European Funds of Regional Development
ID : BWF/H/52228/2012/13. 10.10-1/3.4,6
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