Identification of Z-Tyr-Ala-CHN
SARS-CoV-2
cathepsin L inhibitor
coronavirus
in vitro
phenotypic screening
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
10 Mar 2023
10 Mar 2023
Historique:
received:
13
01
2023
revised:
17
02
2023
accepted:
07
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
The ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is partly under control by vaccination. However, highly potent and safe antiviral drugs for SARS-CoV-2 are still needed to avoid development of severe COVID-19. We report the discovery of a small molecule, Z-Tyr-Ala-CHN
Identifiants
pubmed: 36985290
pii: microorganisms11030717
doi: 10.3390/microorganisms11030717
pmc: PMC10055926
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : ASPR HHS
ID : HHSO100201700018C
Pays : United States
Organisme : Advanced Research and Development Authority (BARDA)
ID : HHSO100201800012C
Organisme : Janssen Research & Development
ID : N/A
Organisme : Corona Accelerated R&D in Europe (CARE) project with the Innovative Medicines Initiative 2 Joint Undertaking (JU). The JU receives support from the European Union's Horizon 2020 research and innovation program, EFPIA, Bill & Melinda Gates Foundation, Glob
ID : 101005077
Organisme : Hercules Foundation (Research Foundation Flanders)
ID : NA
Organisme : Rega Foundation, KU Leuven
ID : NA
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