Minerals and Antioxidant Micronutrients Levels and Clinical Outcome in Older Patients Hospitalized for COVID-19 during the First Wave of the Pandemic.


Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
21 Mar 2023
Historique:
received: 11 02 2023
revised: 17 03 2023
accepted: 18 03 2023
medline: 30 3 2023
entrez: 29 3 2023
pubmed: 30 3 2023
Statut: epublish

Résumé

Excessive inflammatory response has been implicated in severe respiratory forms of coronavirus disease 2019 (COVID-19). Trace elements such as zinc, selenium, and copper are known to modulate inflammation and immunity. This study aimed to assess the relationships between antioxidant vitamins and mineral trace elements levels as well as COVID-19 severity in older adults hospitalized. In this observational retrospective cohort study, the levels of zinc, selenium, copper, vitamin A, β-carotene, and vitamin E were measured in 94 patients within the first 15 days of hospitalization. The outcomes were in-hospital mortality secondary to COVID-19 or severe COVID-19. A logistic regression analysis was conducted to test whether the levels of vitamins and minerals were independently associated with severity. In this cohort (average age of 78 years), severe forms (46%) were associated with lower zinc (

Identifiants

pubmed: 36986247
pii: nu15061516
doi: 10.3390/nu15061516
pmc: PMC10056386
pii:
doi:

Substances chimiques

Antioxidants 0
Trace Elements 0
Vitamin A 11103-57-4
Selenium H6241UJ22B
beta Carotene 01YAE03M7J
Copper 789U1901C5
Ascorbic Acid PQ6CK8PD0R
Vitamins 0
Minerals 0
Zinc J41CSQ7QDS
Micronutrients 0

Types de publication

Observational Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Hospices Civils de Lyon
ID : NCT04877509

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Auteurs

Clément Lahaye (C)

Department of Geriatric Medicine, Hôpital Gabriel Montpied, 63000 Clermont-Ferrand, France.
Unité de Nutrition Humaine, Université Clermont Auvergne, INRAE, 63000 Clermont-Ferrand, France.

François Parant (F)

Biology Center South, Hôpital Lyon Sud, 69310 Pierre-Bénite, France.

Julie Haesebaert (J)

Public Health Unit, Department of Clinical Research and Epidemiology, Groupement Hospitalier Est, 69002 Lyon, France.
RESHAPE Research on Healthcare Performance Inserm U1290, Université Lyon 1, 69008 Lyon, France.

Karine Goldet (K)

Clinical Research Centre, Ageing, Brain, Fragility-Hôpital des Charpennes, 69100 Villeurbanne, France.

Lamia Bendim'red (L)

Clinical Research Centre, Ageing, Brain, Fragility-Hôpital des Charpennes, 69100 Villeurbanne, France.

Laetitia Henaff (L)

Department of Hygiene, Epidemiology and Prevention, Hôpital Édouard Herriot, Hospices Civils de Lyon, 69003 Lyon, France.
ICIR-International Center for Infectiology Research (Team PHE3ID), Claude Bernard Lyon 1 University, Inserm, U1111, CNRS, UMR5308, ENS Lyon, 46 Allée d'Italie, 69007 Lyon, France.

Mitra Saadatian-Elahi (M)

Department of Hygiene, Epidemiology and Prevention, Hôpital Édouard Herriot, Hospices Civils de Lyon, 69003 Lyon, France.
ICIR-International Center for Infectiology Research (Team PHE3ID), Claude Bernard Lyon 1 University, Inserm, U1111, CNRS, UMR5308, ENS Lyon, 46 Allée d'Italie, 69007 Lyon, France.

Philippe Vanhems (P)

Department of Hygiene, Epidemiology and Prevention, Hôpital Édouard Herriot, Hospices Civils de Lyon, 69003 Lyon, France.
ICIR-International Center for Infectiology Research (Team PHE3ID), Claude Bernard Lyon 1 University, Inserm, U1111, CNRS, UMR5308, ENS Lyon, 46 Allée d'Italie, 69007 Lyon, France.

Charlotte Cuerq (C)

Biology Center South, Hôpital Lyon Sud, 69310 Pierre-Bénite, France.

Thomas Gilbert (T)

RESHAPE Research on Healthcare Performance Inserm U1290, Université Lyon 1, 69008 Lyon, France.
Department of Geriatric Medicine, Groupement Hospitalier Sud, CHU de Lyon, 69495 Pierre-Bénite, France.

Emilie Blond (E)

Biology Center South, Hôpital Lyon Sud, 69310 Pierre-Bénite, France.

Muriel Bost (M)

Biology Center South, Hôpital Lyon Sud, 69310 Pierre-Bénite, France.

Marc Bonnefoy (M)

Department of Geriatric Medicine, Groupement Hospitalier Sud, CHU de Lyon, 69495 Pierre-Bénite, France.
INSERM, 1060 CaRMeN 165 Chemin du Grand Revoyet, 69310 Pierre-Bénite, France.

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Classifications MeSH