Anti-Inflammatory, Antioxidant, and WAT/BAT-Conversion Stimulation Induced by Novel PPAR Ligands: Results from Ex Vivo and In Vitro Studies.

PPAR modulators UCP1 adipose tissue obesity

Journal

Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453

Informations de publication

Date de publication:
24 Feb 2023
Historique:
received: 31 01 2023
revised: 21 02 2023
accepted: 21 02 2023
medline: 30 3 2023
entrez: 29 3 2023
pubmed: 30 3 2023
Statut: epublish

Résumé

Activation of peroxisome proliferator-activated receptors (PPARs) not only regulates multiple metabolic pathways, but mediates various biological effects related to inflammation and oxidative stress. We investigated the effects of four new PPAR ligands containing a fibrate scaffold-the PPAR agonists (

Identifiants

pubmed: 36986448
pii: ph16030346
doi: 10.3390/ph16030346
pmc: PMC10056895
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Lucia Recinella (L)

Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.

Barbara De Filippis (B)

Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.

Maria Loreta Libero (ML)

Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.

Alessandra Ammazzalorso (A)

Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.

Annalisa Chiavaroli (A)

Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.

Giustino Orlando (G)

Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.

Claudio Ferrante (C)

Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.

Letizia Giampietro (L)

Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.

Serena Veschi (S)

Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.

Alessandro Cama (A)

Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.

Federica Mannino (F)

Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.

Irene Gasparo (I)

Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.

Alessandra Bitto (A)

Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.

Rosa Amoroso (R)

Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.

Luigi Brunetti (L)

Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.

Sheila Leone (S)

Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.

Classifications MeSH