Suramin Affects the Renal VEGF-A/VEGFR Axis in Short-Term Streptozotocin-Induced Diabetes.
VEGF-A
VEGFR1
VEGFR2
diabetes mellitus
diabetic nephropathy
streptozotocin
suramin
vascular endothelial growth factor A
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
22 Mar 2023
22 Mar 2023
Historique:
received:
21
02
2023
revised:
15
03
2023
accepted:
20
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
Diabetic nephropathy (DN) accounts for approximately 50% of end-stage renal diseases. Vascular endothelial growth factor A (VEGF-A) is thought to be a critical mediator of vascular dysfunction in DN, but its role is unclear. The lack of pharmacological tools to modify renal concentrations further hinders the understanding of its role in DN. In this study, rats were evaluated after 3 weeks of streptozotocin-induced diabetes and two suramin treatments (10 mg/kg,
Identifiants
pubmed: 36986570
pii: ph16030470
doi: 10.3390/ph16030470
pmc: PMC10053825
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Centre for Research and Development
ID : project POWR.03.02.00-00-I014/17-00
Organisme : Ministry of Science and Higher Education
ID : 01-50022 / 643-0003381
Organisme : Gdańsk Medical University
ID : 71-01415/0004593/61/524/524/2022
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