Preparation of Apixaban Solid Dispersion for the Enhancement of Apixaban Solubility and Permeability.
anticoagulation
apixaban
bioavailability enhancement
solid dispersion
solubility enhancement
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
10 Mar 2023
10 Mar 2023
Historique:
received:
25
01
2023
revised:
27
02
2023
accepted:
06
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
(1) Background: Solid dispersion (SD) can help increase the bioavailability of poorly water-soluble drugs. Meanwhile, apixaban (APX)-a new anticoagulation drug-has low water solubility (0.028 mg/mL) and low intestinal permeability (0.9 × 10
Identifiants
pubmed: 36986767
pii: pharmaceutics15030907
doi: 10.3390/pharmaceutics15030907
pmc: PMC10057842
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Research Foundation of Korea
ID : NRF-2021R1A2C2008834
Organisme : National Research Foundation of Korea
ID : University-Centered Labs-2018R1A6A1A03023718
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