Exploiting Nanomedicine for Cancer Polychemotherapy: Recent Advances and Clinical Applications.
cancer therapy
nanocarriers
polychemotherapy
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
14 Mar 2023
14 Mar 2023
Historique:
received:
20
01
2023
revised:
07
03
2023
accepted:
10
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
The most important limitations of chemotherapeutic agents are severe side effects and the development of multi-drug resistance. Recently, the clinical successes achieved with immunotherapy have revolutionized the treatment of several advanced-stage malignancies, but most patients do not respond and many of them develop immune-related adverse events. Loading synergistic combinations of different anti-tumor drugs in nanocarriers may enhance their efficacy and reduce life-threatening toxicities. Thereafter, nanomedicines may synergize with pharmacological, immunological, and physical combined treatments, and should be increasingly integrated in multimodal combination therapy regimens. The goal of this manuscript is to provide better understanding and key considerations for developing new combined nanomedicines and nanotheranostics. We will clarify the potential of combined nanomedicine strategies that are designed to target different steps of the cancer growth as well as its microenvironment and immunity interactions. Moreover, we will describe relevant experiments in animal models and discuss issues raised by translation in the human setting.
Identifiants
pubmed: 36986798
pii: pharmaceutics15030937
doi: 10.3390/pharmaceutics15030937
pmc: PMC10057931
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Italian Association for Cancer Research
ID : IG 20714
Organisme : Compagnia di San Paolo
ID : Bando ex post 2020, "An innovative Nanotechnology for Glioma Chemotherapy"
Organisme : Fondazione Cariplo
ID : 2017-0535
Organisme : University of Turin
ID : Ricerca Locale 2019-22
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