An Enhanced Dissolving Cyclosporin-A Inhalable Powder Efficiently Reduces SARS-CoV-2 Infection In Vitro.
SARS-CoV-2
cyclosporine-A
cytokine storm
dry powder inhaler
spray-drying
transplant rejection
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
22 Mar 2023
22 Mar 2023
Historique:
received:
08
02
2023
revised:
08
03
2023
accepted:
18
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
This work illustrates the development of a dry inhalation powder of cyclosporine-A for the prevention of rejection after lung transplantation and for the treatment of COVID-19. The influence of excipients on the spray-dried powder's critical quality attributes was explored. The best-performing powder in terms of dissolution time and respirability was obtained starting from a concentration of ethanol of 45% (
Identifiants
pubmed: 36986883
pii: pharmaceutics15031023
doi: 10.3390/pharmaceutics15031023
pmc: PMC10055879
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
EClinicalMedicine. 2020 Nov;28:100591
pubmed: 33078138
Int J Pharm. 2012 Apr 15;426(1-2):302-306
pubmed: 22285473
Lancet. 1991 Dec 14;338(8781):1488-90
pubmed: 1683920
Eur J Pharm Sci. 2010 Jun 14;40(3):239-47
pubmed: 20371286
Pharmazie. 2008 Apr;63(4):319-20
pubmed: 18468395
Clin Pharmacol Ther. 1995 Nov;58(5):492-7
pubmed: 7586942
STAR Protoc. 2020 Sep 18;1(2):
pubmed: 32995754
Eur J Pharm Sci. 2017 Jan 1;96:107-114
pubmed: 27634579
Am J Transplant. 2022 Jan;22(1):9-11
pubmed: 34699688
N Engl J Med. 2006 Jan 12;354(2):141-50
pubmed: 16407509
Eur J Pharm Biopharm. 2015 Jun;93:165-72
pubmed: 25845771
Clin Chem Lab Med. 2007;45(8):1098-104
pubmed: 17868000
Clin Pharmacokinet. 2008;47(11):733-42
pubmed: 18840028
Clin Infect Dis. 2023 Jan 6;76(1):165-171
pubmed: 35245942
Curr Protoc Microbiol. 2008 Nov;Appendix 4:Appendix 4E
pubmed: 19016439
Eur Respir J. 2003 Dec;22(6):1007-18
pubmed: 14680094
Pharmaceutics. 2021 Sep 23;13(10):
pubmed: 34683833
ERJ Open Res. 2019 Oct 30;5(4):
pubmed: 31687370
N Engl J Med. 2022 Feb 10;386(6):509-520
pubmed: 34914868
Virology. 2011 Mar 15;411(2):374-82
pubmed: 21295323
Fundam Clin Pharmacol. 2021 Apr;35(2):446-454
pubmed: 32734681
Am J Med. 1984 Oct;77(4):652-6
pubmed: 6486141
J Aerosol Med Pulm Drug Deliv. 2009 Jun;22(2):121-30
pubmed: 19422312
Cell Mol Biol Lett. 2009;14(1):139-52
pubmed: 19005620
Int J Nanomedicine. 2013;8:1269-83
pubmed: 23569375
N Engl J Med. 2021 Nov 18;385(21):1941-1950
pubmed: 34706189
Eur J Pharm Sci. 2022 Jan 1;168:106036
pubmed: 34637896
Pharmaceutics. 2021 Nov 16;13(11):
pubmed: 34834351
Transplant Proc. 2004 Mar;36(2 Suppl):318S-322S
pubmed: 15041361
Eur Respir J. 2020 Nov 26;56(5):
pubmed: 32732332
Lancet Respir Med. 2022 Apr;10(4):327-336
pubmed: 35123660
Ann Pharmacother. 2007 Jul;41(7):1277-80
pubmed: 17609240
J Heart Lung Transplant. 2002 Mar;21(3):297-310
pubmed: 11897517
Virol Sin. 2021 Feb;36(1):141-144
pubmed: 32458296
Pharmacol Rev. 2022 Jan;74(1):48-118
pubmed: 34987088
J Pharm Pharmacol. 1972 Dec;24(12):979-81
pubmed: 4146531
ACS Omega. 2019 May 01;4(5):7938-7943
pubmed: 31459882
J Gen Virol. 2011 Nov;92(Pt 11):2542-2548
pubmed: 21752960
Microbiol Spectr. 2022 Feb 23;10(1):e0150421
pubmed: 34985303
Viruses. 2013 May 22;5(5):1250-60
pubmed: 23698397
Jpn J Infect Dis. 2021 Jul 21;74(4):293-298
pubmed: 33250487
Front Immunol. 2019 Jul 17;10:1681
pubmed: 31379869
Am J Transplant. 2021 Jul;21(7):2360-2371
pubmed: 33249747
Pharm Res. 2016 Sep;33(9):2107-16
pubmed: 27225495
Artif Cells Nanomed Biotechnol. 2018;46(sup2):552-564
pubmed: 29688042
Nat Med. 2022 Jan;28(1):201-211
pubmed: 34782790
Infection. 2021 Jun;49(3):401-410
pubmed: 33389708
Eur Respir J. 2004 Mar;23(3):378-83
pubmed: 15065825
Pharmaceutics. 2021 Jul 21;13(8):
pubmed: 34452073
AAPS J. 2017 Mar;19(2):578-586
pubmed: 28070713
Am J Transplant. 2022 Jan;22(1):222-229
pubmed: 34587371
Nat Rev Rheumatol. 2017 Jul;13(7):399-409
pubmed: 28615731
J Aerosol Med Pulm Drug Deliv. 2010 Feb;23(1):31-9
pubmed: 19580368
Drugs. 2022 Apr;82(5):585-591
pubmed: 35305258
Clin Pharmacokinet. 1993 Jun;24(6):472-95
pubmed: 8513650
Vet Rec. 2014 Mar;174 Suppl 2:13-21
pubmed: 24682697
Int J Pharm. 2011 Nov 25;420(1):34-42
pubmed: 21864662
ACS Chem Neurosci. 2021 Mar 3;12(5):930-944
pubmed: 33606519
JCI Insight. 2022 Jun 8;7(11):
pubmed: 35536669