Peripheral Mononuclear Cells Surface Markers Evaluation in Different Stages of Hepatocellular Carcinoma; in a Trial for Early and Accurate Diagnosis in Patients with Post-Hepatitis Liver Cirrhosis and Unremarkable Raised AFP.
Barcelona clinic liver cancer
hepatocellular carcinoma
lymphocyte subset
metastases (M)
monocyte subpopulation
nodes (N)
tumor (T)
Journal
International journal of general medicine
ISSN: 1178-7074
Titre abrégé: Int J Gen Med
Pays: New Zealand
ID NLM: 101515487
Informations de publication
Date de publication:
2023
2023
Historique:
received:
17
01
2023
accepted:
07
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
HCC is frequently diagnosed late, when only palliative treatment is available. So, we try to use different immunological markers to identify early HCC in patients with unremarkable raised AFP. This study was conducted on 112 participants divided into two equal groups: Group I, 56 patients with liver cirrhosis and different stages of HCC; Group II, 56 patients with liver cirrhosis. The diagnosis of HCC was based on AASLD guidelines. TNM and BCLC classification systems are used for staging of HCC. A significant reduction in the median percentage of lymphocyte subset (CD3 Patients with HCC with unremarkable raised AFP showed marked reduction in lymphocytes, natural killer cells, and all monocyte subpopulations. In addition, patients with advanced HCC showed increased CD33
Identifiants
pubmed: 36987406
doi: 10.2147/IJGM.S404914
pii: 404914
pmc: PMC10040161
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1047-1058Informations de copyright
© 2023 Osman et al.
Déclaration de conflit d'intérêts
The authors declare that there are no competing interests associated with this work.
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