Prevalence and Determinants of Fatigue in Patients with IBD: A Cross-Sectional Survey from the GETAID.
Crohn’s disease
disability
fatigue
inflammatory bowel disease
ulcerative colitis
Journal
Journal of Crohn's & colitis
ISSN: 1876-4479
Titre abrégé: J Crohns Colitis
Pays: England
ID NLM: 101318676
Informations de publication
Date de publication:
20 Oct 2023
20 Oct 2023
Historique:
pubmed:
30
3
2023
medline:
30
3
2023
entrez:
29
3
2023
Statut:
ppublish
Résumé
Fatigue is commonly reported by patients with inflammatory bowel disease [IBD], but the determinants of IBD-related fatigue have yet to be determined. To identify the factors associated with fatigue in a large population of patients with IBD. Fatigue and nine other IBD-related disability dimensions were assessed in a cohort of 1704 consecutive patients with IBD using the IBD-disk questionnaire in a cross-sectional survey of 42 French and Belgian centres. Fatigue and severe fatigue were defined as energy subscores >5 and >7, respectively. Determinants of fatigue were assessed using univariate and multivariate analyses (odds ratios [ORs] are provided with 95% confidence intervals). The prevalence rates of fatigue and severe fatigue were 54.1% and 37.1%, respectively. Both fatigue and severe fatigue were significantly higher in patients with active disease than in patients with inactive disease [64.9% vs 44.7% and 47.4% vs 28.6%, respectively; p < 0.001 for both comparisons]. In the multivariate analysis stratified by age, sex, type of IBD and IBD activity, fatigue was associated with age >40 years (OR = 0.71 [0.54-0.93]), female sex (OR = 1.48 [1.13-1.93]) and IBD-related sick leave (OR = 1.61 [1.19-2.16]), and joint pain (OR = 1.60 [1.17-2.18]), abdominal pain (OR = 1.78 [1.29-2.45]), regulating defecation (OR = 1.67 [1.20-2.32]), education and work (OR = 1.96 [1.40-2.75]), body image (OR = 1.38 [1.02-1.86]), sleep (OR = 3.60 [2.66-4.88]) and emotions (OR = 3.60 [2.66-4.88]) subscores >5. Determinants of fatigue are not restricted to IBD-related factors but also include social factors, sleep and emotional disturbances, thus supporting a holistic approach to IBD patient care.
Sections du résumé
BACKGROUND
BACKGROUND
Fatigue is commonly reported by patients with inflammatory bowel disease [IBD], but the determinants of IBD-related fatigue have yet to be determined.
AIMS
OBJECTIVE
To identify the factors associated with fatigue in a large population of patients with IBD.
PATIENTS AND METHODS
METHODS
Fatigue and nine other IBD-related disability dimensions were assessed in a cohort of 1704 consecutive patients with IBD using the IBD-disk questionnaire in a cross-sectional survey of 42 French and Belgian centres. Fatigue and severe fatigue were defined as energy subscores >5 and >7, respectively. Determinants of fatigue were assessed using univariate and multivariate analyses (odds ratios [ORs] are provided with 95% confidence intervals).
RESULTS
RESULTS
The prevalence rates of fatigue and severe fatigue were 54.1% and 37.1%, respectively. Both fatigue and severe fatigue were significantly higher in patients with active disease than in patients with inactive disease [64.9% vs 44.7% and 47.4% vs 28.6%, respectively; p < 0.001 for both comparisons]. In the multivariate analysis stratified by age, sex, type of IBD and IBD activity, fatigue was associated with age >40 years (OR = 0.71 [0.54-0.93]), female sex (OR = 1.48 [1.13-1.93]) and IBD-related sick leave (OR = 1.61 [1.19-2.16]), and joint pain (OR = 1.60 [1.17-2.18]), abdominal pain (OR = 1.78 [1.29-2.45]), regulating defecation (OR = 1.67 [1.20-2.32]), education and work (OR = 1.96 [1.40-2.75]), body image (OR = 1.38 [1.02-1.86]), sleep (OR = 3.60 [2.66-4.88]) and emotions (OR = 3.60 [2.66-4.88]) subscores >5.
CONCLUSION
CONCLUSIONS
Determinants of fatigue are not restricted to IBD-related factors but also include social factors, sleep and emotional disturbances, thus supporting a holistic approach to IBD patient care.
Identifiants
pubmed: 36988620
pii: 7093159
doi: 10.1093/ecco-jcc/jjad060
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1418-1425Subventions
Organisme : Abbvie
Investigateurs
Aurelien Amiot
(A)
Sara Tadbiri
(S)
Charlotte Gagniere
(C)
Jenny Tannoury
(J)
Maria Nachury
(M)
Benjamin Pariente
(B)
Pauline Wils
(P)
Yoram Bouhnik
(Y)
Carmen Stefanescu
(C)
Xavier Treton
(X)
Carole Martins
(C)
Mathieu Uzzan
(M)
Melanie Serrero
(M)
Jerome Filippi
(J)
Xavier Hébuterne
(X)
Nadia Arab
(N)
Virginie Cluzeau
(V)
Xavier Roblin
(X)
Emilie Del Tedesco
(E)
Laurent Beaugerie
(L)
Philippe Seksik
(P)
Anne Bourrier
(A)
Cecilia Landmann
(C)
Julien Kirchgesner
(J)
Harry Sokol
(H)
Guillaume Bouguen
(G)
Laurent Siproudhis
(L)
Marie DeWitte
(M)
Denis Franchimont
(D)
Guillaume Savoye
(G)
Anthony Buisson
(A)
Edouard Louis
(E)
Catherine Reenaers
(C)
Stephane Nancey
(S)
Gilles Boschetti
(G)
Claire Gay
(C)
Pauline Danion
(P)
Bernard Flourié
(B)
Vered Abitbol
(V)
Georgia Malamut
(G)
Jean-Marie Reimund
(JM)
Benedicte Caron
(B)
Olivier DeWitt
(O)
Lucine Vuitton
(L)
Nicolas Mathieu
(N)
Sandie Pestour
(S)
Thomas Chateau
(T)
Laurent Peyrin-Biroulet
(L)
Camille Zallot
(C)
Cyrielle Gilletta
(C)
Matthieu Allez
(M)
Jean-Marc Gornet
(JM)
Clotilde Baudry
(C)
Stephanie Viennot
(S)
Arnaud Bourreille
(A)
Caroline Trang-Poisson
(C)
Nina Dib
(N)
Hedi Brixi
(H)
Guillaume Cadiot
(G)
Medina Boualit
(M)
Claire Painchart
(C)
Laurianne Plastaras
(L)
Romain Altwegg
(R)
Lucile Boivineau
(L)
Mathurin Fumery
(M)
Ludovic Caillo
(L)
David Laharie
(D)
Pauline Riviere
(P)
Florian Poullenot
(F)
Benoit Coffin
(B)
Henri Duboc
(H)
Stephane Nahon
(S)
Noemie Tavernier
(N)
Marion Simon
(M)
Baya Coulibaly
(B)
Morgane Amil
(M)
Duveau Nicolas
(D)
Sherine Khater
(S)
Mehdi Kaassis
(M)
Felix Goutorbe
(F)
Driffa Moussata
(D)
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For permissions, please email: journals.permissions@oup.com.