Role of PI(4,5)P2 and Cholesterol in Unconventional Protein Secretion.
Cholesterol
FGF2
HIV Tat
Homeoprotein
Phosphatidylinositol(4,5)bisphosphate
Translocation
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
31
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
ppublish
Résumé
Besides its protective role in the maintenance of cell homeostasis, the plasma membrane is the site of exchanges between the cell interior and the extracellular medium. To circumvent the hydrophobic barrier formed by the acyl chains of the lipid bilayer, protein channels and transporters are key players in the exchange of small hydrophilic compounds such as ions or nutrients, but they hardly account for the transport of larger biological molecules. Exchange of proteins usually relies on membrane-fusion events between vesicles and the plasma membrane. In recent years, several alternative unconventional protein secretion (UPS) pathways across the plasma membrane have been characterised for a specific set of secreted substrates, some of them excluding any membrane-fusion events (Dimou and Nickel, Curr Biol 28:R406-R410, 2018). One of thesbe pathways, referred as type I UPS, relies on the direct translocation of the protein across the plasma membrane and not surprisingly, lipids are essential players in this process. In this chapter, we discuss the roles of phosphatidylinositol(4,5)bisphosphate (PI(4,5)P2) and cholesterol in unconventional pathways involving Engrailed-2 homeoprotein and fibroblast growth factor 2.
Identifiants
pubmed: 36988889
doi: 10.1007/978-3-031-21547-6_14
doi:
Substances chimiques
Lipid Bilayers
0
Membrane Transport Proteins
0
Cholesterol
97C5T2UQ7J
Phosphatidylinositol 4,5-Diphosphate
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
381-392Informations de copyright
© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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