Asthma and increased risk of myocardial infarction and mortality among hypertensive Korean patients.
Asthma
Hypertension
Mortality
Myocardial infarction
Risk factor
Journal
Hypertension research : official journal of the Japanese Society of Hypertension
ISSN: 1348-4214
Titre abrégé: Hypertens Res
Pays: England
ID NLM: 9307690
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
received:
16
02
2022
accepted:
03
03
2023
revised:
25
02
2023
medline:
6
7
2023
pubmed:
30
3
2023
entrez:
29
3
2023
Statut:
ppublish
Résumé
This study aimed to evaluate the effects of asthma on cardiovascular disease incidence in patients with hypertension. A total of 639,784 patients with hypertension from the Korea National Health Insurance Service database were included, of whom 62,517 had history of asthma after propensity score matching. The risks of all-cause mortality, myocardial infarction (MI), stroke, and end-stage renal disease (ESRD) were assessed according to the presence of asthma, long-acting β2-agonist (LABA) inhaler usage, and/or systemic corticosteroid usage for up to 11 years. In addition, whether these risks were modified by average blood pressure (BP) levels during the follow-up period was examined. Asthma was associated with an increased risk of all-cause mortality (hazard ratio [HR], 1.203; 95% confidence interval [CI], 1.165-1.241) and MI (HR, 1.244; 95% CI, 1.182-1.310) but not the risk of stroke or ESRD. LABA inhaler usage was associated with a higher risk of all-cause mortality and MI, and systemic corticosteroids usage showed a higher risk of ESRD as well as all-cause mortality and MI among hypertensive patients with asthma. Compared to patients without asthma, there was a graded increase in the risk of all-cause mortality and MI in those with asthma without LABA inhaler/systemic corticosteroid usage and in those with asthma with LABA inhaler/systemic corticosteroid usage. These associations were not significantly modified by BP levels. This nationwide population-based study supports that asthma may be a clinical factor that increases the risk of poor outcomes in patients with hypertension.
Identifiants
pubmed: 36991063
doi: 10.1038/s41440-023-01257-3
pii: 10.1038/s41440-023-01257-3
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1694-1704Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2023. The Author(s), under exclusive licence to The Japanese Society of Hypertension.
Références
Stebbings JH Jr. Two observed associations between respiratory allergies and hypertension in nonsmokers. Am J Epidemiol. 1973;97:4–15.
doi: 10.1093/oxfordjournals.aje.a121482
pubmed: 4684067
Christiansen SC, Schatz M, Yang SJ, Ngor E, Chen W, Zuraw BL. Hypertension and asthma: a comorbid relationship. J Allergy Clin Immunol Pr. 2016;4:76–81.
doi: 10.1016/j.jaip.2015.07.009
Ferguson S, Teodorescu MC, Gangnon RE, Peterson AG, Consens FB, Chervin RD, et al. Factors associated with systemic hypertension in asthma. Lung. 2014;192:675–83.
doi: 10.1007/s00408-014-9600-y
pubmed: 24920421
pmcid: 4543317
Jacobs DR Jr, Yatsuya H, Hearst MO, Thyagarajan B, Kalhan R, Rosenberg S, et al. Rate of decline of forced vital capacity predicts future arterial hypertension: the Coronary Artery Risk Development in Young Adults Study. Hypertension. 2012;59:219–25.
doi: 10.1161/HYPERTENSIONAHA.111.184101
pubmed: 22203738
Christiansen SC, Zuraw BL. Treatment of hypertension in patients with asthma. N Engl J Med. 2019;381:1046–57.
doi: 10.1056/NEJMra1800345
pubmed: 31509675
Cepelis A, Brumpton BM, Laugsand LE, Dalen H, Langhammer A, Janszky I, et al. asthma control and risk of acute myocardial infarction: HUNT study. Eur J Epidemiol. 2019;34:967–77.
doi: 10.1007/s10654-019-00562-x
pubmed: 31512117
Duong M, Islam S, Rangarajan S, Leong D, Kurmi O, Teo K, et al. Mortality and cardiovascular and respiratory morbidity in individuals with impaired FEV(1) (PURE): an international, community-based cohort study. Lancet Glob Health. 2019;7:e613–e623.
doi: 10.1016/S2214-109X(19)30070-1
pubmed: 31000131
Strand LB, Tsai MK, Wen CP, Chang SS, Brumpton BM. Is having asthma associated with an increased risk of dying from cardiovascular disease? A prospective cohort study of 446346 Taiwanese adults. BMJ Open. 2018;8:e019992.
doi: 10.1136/bmjopen-2017-019992
pubmed: 29858410
pmcid: 5988076
Xu M, Xu J, Yang X. Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis. Ann Saudi Med. 2017;37:99–105.
doi: 10.5144/0256-4947.2017.99
pubmed: 28377538
pmcid: 6150547
Seong SC, Kim YY, Park SK, Khang YH, Kim HC, Park JH, et al. Cohort profile: the National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) in Korea. BMJ Open. 2017;7:e016640.
doi: 10.1136/bmjopen-2017-016640
pubmed: 28947447
pmcid: 5623538
Lee CJ, Hwang J, Oh J, Lee SH, Kang SM, Kim HC, et al. Relation between blood pressure and clinical outcome in hypertensive subjects with previous stroke. J Am Heart Assoc. 2017;6:e007102.
doi: 10.1161/JAHA.117.007102
pubmed: 29212651
pmcid: 5779023
Shin JY, Sohn KH, Shin JE, Park M, Lim J, Lee JY, et al. Changing patterns of adult asthma incidence: results from the National Health Insurance Service-National Sample Cohort (NHIS-NSC) database in Korea. Sci Rep. 2018;8:15052.
doi: 10.1038/s41598-018-33316-y
pubmed: 30302007
pmcid: 6177405
Lee CJ, Hwang J, Lee YH, Oh J, Lee SH, Kang SM, et al. Blood pressure level associated with lowest cardiovascular event in hypertensive diabetic patients. J Hypertens. 2018;36:2434–43.
doi: 10.1097/HJH.0000000000001842
pubmed: 30015754
Lee CJ, Ryu J, Kim HC, Ryu DR, Ihm SH, Kim YJ, et al. Clinical benefit of treatment of stage-1, low-risk hypertension. Hypertension. 2018;72:1285–93.
doi: 10.1161/HYPERTENSIONAHA.118.11787
pubmed: 30571236
Ko MJ, Jo AJ, Park CM, Kim HJ, Kim YJ, Park DW. Level of blood pressure control and cardiovascular events: SPRINT criteria versus the 2014 hypertension recommendations. J Am Coll Cardiol. 2016;67:2821–31.
doi: 10.1016/j.jacc.2016.03.572
pubmed: 27311520
Fine JP, Gray RJ. A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc. 1999;94:496–509.
doi: 10.1080/01621459.1999.10474144
Dogra S, Ardern CI, Baker J. The relationship between age of asthma onset and cardiovascular disease in Canadians. J Asthma. 2007;44:849–54.
doi: 10.1080/02770900701752391
pubmed: 18097862
Liu H, Fu Y, Wang K. Asthma and risk of coronary heart disease: a meta-analysis of cohort studies. Ann Allergy Asthma Immunol. 2017;118:689–95.
doi: 10.1016/j.anai.2017.03.012
pubmed: 28433577
Bang DW, Wi CI, Kim EN, Hagan J, Roger V, Manemann S, et al. Asthma status and risk of incident myocardial infarction: a population-based case-control study. J Allergy Clin Immunol Pr. 2016;4:917–23.
doi: 10.1016/j.jaip.2016.02.018
Raita Y, Camargo CA Jr, Faridi MK, Brown DFM, Shimada YJ, Hasegawa K. Risk of acute myocardial infarction and ischemic stroke in patients with asthma exacerbation: a population-based, self-controlled case series study. J Allergy Clin Immunol Pr. 2020;8:188–94.e188.
doi: 10.1016/j.jaip.2019.06.043
Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH guidelines for the management of arterial hypertension. Eur Heart J. 2018;39:3021–104.
doi: 10.1093/eurheartj/ehy339
pubmed: 30165516
Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2018;71:e127–e248.
doi: 10.1016/j.jacc.2017.11.006
pubmed: 29146535
Chung WS, Lin CL, Chen YF, Ho FM, Hsu WH, Kao CH. Increased stroke risk among adult asthmatic patients. Eur J Clin Invest. 2014;44:1025–33.
doi: 10.1111/eci.12336
pubmed: 25207756
Kim SY, Lim H, Lim JS, Choi HG. Analysis of the relationship between adult asthma and stroke: a longitudinal follow-up study using the Korean national sample cohort. Biomed Res Int. 2019;2019:8919230.
doi: 10.1155/2019/8919230
pubmed: 31317041
pmcid: 6601683
Fang ZH, Li ZF, An ZY, Huang SC, Hao MD, Zhang WX. Meta-analysis of the association between asthma and the risk of stroke. Front Neurol. 2022;13:900438.
doi: 10.3389/fneur.2022.900438
pubmed: 35812117
pmcid: 9263265
Kim HC, Oh SM. Noncommunicable diseases: current status of major modifiable risk factors in Korea. J Prev Med Public Health. 2013;46:165–72.
doi: 10.3961/jpmph.2013.46.4.165
pubmed: 23946874
pmcid: 3740221
Spitzer WO, Suissa S, Ernst P, Horwitz RI, Habbick B, Cockcroft D, et al. The use of beta-agonists and the risk of death and near death from asthma. N Engl J Med. 1992;326:501–6.
doi: 10.1056/NEJM199202203260801
pubmed: 1346340
Wang MT, Liou JT, Lin CW, Tsai CL, Wang YH, Hsu YJ, et al. Association of cardiovascular risk with inhaled long-acting bronchodilators in patients with chronic obstructive pulmonary disease: a nested case-control study. JAMA Intern Med. 2018;178:229–38.
doi: 10.1001/jamainternmed.2017.7720
pubmed: 29297057
pmcid: 5838614
Li C, Cheng W, Guo J, Guan W. Relationship of inhaled long-acting bronchodilators with cardiovascular outcomes among patients with stable COPD: a meta-analysis and systematic review of 43 randomized trials. Int J Chron Obstruct Pulmon Dis. 2019;14:799–808.
doi: 10.2147/COPD.S198288
pubmed: 31114181
pmcid: 6489598
Ish P, Malhotra N, Gupta N. GINA 2020: what’s new and why? J Asthma. 2021;58:1273–7.
Global Strategy for Asthma Management and Prevention. 2010. https://ginasthma.org/archived-reports/ . Accessed 5 May 2020.
Volmer T, Effenberger T, Trautner C, Buhl R. Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature. Eur Respir J. 2018;52:1800703.
doi: 10.1183/13993003.00703-2018
pubmed: 30190274
Sweeney J, Patterson CC, Menzies-Gow A, Niven RM, Mansur AH, Bucknall C, et al. Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the Optimum Patient Care Research Database and the British Thoracic Difficult Asthma Registry. Thorax. 2016;71:339–46.
doi: 10.1136/thoraxjnl-2015-207630
pubmed: 26819354
Mebrahtu TF, Morgan AW, West RM, Stewart PM, Pujades-Rodriguez M. Oral glucocorticoids and incidence of hypertension in people with chronic inflammatory diseases: a population-based cohort study. CMAJ. 2020;192:E295–e301.
doi: 10.1503/cmaj.191012
pubmed: 32392512
pmcid: 7101178
Hwang JL, Weiss RE. Steroid-induced diabetes: a clinical and molecular approach to understanding and treatment. Diabetes Metab Res Rev. 2014;30:96–102.
doi: 10.1002/dmrr.2486
pubmed: 24123849
pmcid: 4112077
Lionaki S, Hogan SL, Jennette CE, Hu Y, Hamra JB, Jennette JC, et al. The clinical course of ANCA small-vessel vasculitis on chronic dialysis. Kidney Int. 2009;76:644–51.
doi: 10.1038/ki.2009.218
pubmed: 19536079
pmcid: 2778281
Morales DR. LABA monotherapy in asthma: an avoidable problem. Br J Gen Pr. 2013;63:627–8.
doi: 10.3399/bjgp13X675250
Iribarren C, Tolstykh IV, Miller MK, Sobel E, Eisner MD. Adult asthma and risk of coronary heart disease, cerebrovascular disease, and heart failure: a prospective study of 2 matched cohorts. Am J Epidemiol. 2012;176:1014–24.
doi: 10.1093/aje/kws181
pubmed: 23139248
Song WJ, Kang MG, Chang YS, Cho SH. Epidemiology of adult asthma in Asia: toward a better understanding. Asia Pac Allergy. 2014;4:75–85.
doi: 10.5415/apallergy.2014.4.2.75
pubmed: 24809012
pmcid: 4005350