Interaction analysis of ancestry-enriched variants with APOE-ɛ4 on MCI in the Study of Latinos-Investigation of Neurocognitive Aging.

Humans Aging / genetics Alzheimer Disease / genetics Apolipoprotein E4 / genetics Cognitive Dysfunction / genetics Hispanic or Latino / genetics

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
29 03 2023
Historique:
received: 29 11 2022
accepted: 21 03 2023
medline: 31 3 2023
entrez: 29 3 2023
pubmed: 30 3 2023
Statut: epublish

Résumé

APOE-ɛ4 risk on Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) differs between race/ethnic groups, presumably due to ancestral genomic background surrounding the APOE locus. We studied whether African and Amerindian ancestry-enriched genetic variants in the APOE region modify the effect of the APOE-ɛ4 alleles on Mild Cognitive Impairment (MCI) in Hispanics/Latinos. We defined African and Amerindian ancestry-enriched variants as those common in one Hispanic/Latino parental ancestry and rare in the other two. We identified such variants in the APOE region with a predicted moderate impact based on the SnpEff tool. We tested their interaction with APOE-ɛ4 on MCI in the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) population and African Americans from the Atherosclerosis Risk In Communities (ARIC) study. We identified 5 Amerindian and 14 African enriched variants with an expected moderate effect. A suggestive significant interaction (p-value = 0.01) was found for one African-enriched variant, rs8112679, located in the ZNF222 gene fourth exon. Our results suggest there are no ancestry-enriched variants with large effect sizes of interaction effects with APOE-ɛ4 on MCI in the APOE region in the Hispanic/Latino population. Further studies are needed in larger datasets to identify potential interactions with smaller effect sizes.

Identifiants

DOI: 10.1038/s41598-023-32028-2 PMID: 36991100 PMC: PMC10060219
pubmed: 36991100
doi: 10.1038/s41598-023-32028-2
pii: 10.1038/s41598-023-32028-2
pmc: PMC10060219
doi:

Substances chimiques

Apolipoprotein E4 0
ApoE protein, human 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

5114

Subventions

Organisme : NHLBI NIH HHS
ID : N01HC65236
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL086694
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001I
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG061022
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC65233
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005I
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096899
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003I
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG059299
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL087641
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096814
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072972
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096917
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC65237
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG056952
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC65234
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004I
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062429
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG048642
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054548
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025005
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC65235
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL059367
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096902
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002I
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096812
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004402
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG070644
Pays : United States

Informations de copyright

© 2023. The Author(s).

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Auteurs

Einat Granot-Hershkovitz (E)

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, 221 Longwood Avenue, Suite 225C, Boston, MA, 02115, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.

Rui Xia (R)

Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Yunju Yang (Y)

Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Brian Spitzer (B)

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, 221 Longwood Avenue, Suite 225C, Boston, MA, 02115, USA.

Wassim Tarraf (W)

Institute of Gerontology, Wayne State University, Detroit, MI, USA.

Priscilla M Vásquez (PM)

Department of Urban Public Health, Charles R. Drew University of Medicine, Willowbrook, CA, USA.

Richard B Lipton (RB)

Albert Einstein College of Medicine, Montefiore Headache Center, Bronx, NY, USA.

Martha Daviglus (M)

Institute for Minority Health Research, University of Illinois College of Medicine, Chicago, USA.

Maria Argos (M)

Division of Epidemiology and Biostatistics, University of Illinois at Chicago School of Public Health, Chicago, IL, USA.

Jianwen Cai (J)

Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Robert Kaplan (R)

Department of Epidemiology and Population Health, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Myriam Fornage (M)

Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Charles DeCarli (C)

Department of Neurology, Center for Neuroscience, University of California at Davis, Sacramento, CA, USA.

Hector M Gonzalez (HM)

Department of Neurosciences and Shiley-Marcos Alzheimer's Disease Center, University of California, San Diego, La Jolla, CA, USA.

Tamar Sofer (T)

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, 221 Longwood Avenue, Suite 225C, Boston, MA, 02115, USA. tsofer@bwh.harvard.edu.
Department of Medicine, Harvard Medical School, Boston, MA, USA. tsofer@bwh.harvard.edu.
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. tsofer@bwh.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Interaction analysis of ancestry-enriched...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Interaction analysis of ancestry-enriched...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Interaction analysis of ancestry-enriched...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Apolipoprotéine E4 › Interaction analysis of ancestry-enriched...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Interaction analysis of ancestry-enriched...
questionsmedicales.fr › Personnes › Nord-Américains › Groupes de population aux États-Unis › Hispanique ou Latino › Interaction analysis of ancestry-enriched...