Natural history of spinal cord metastasis from brain glioblastomas.

Adult Humans Middle Aged Glioblastoma / pathology Spinal Cord Neoplasms / diagnostic imaging Brain / pathology Brain Neoplasms Prognosis Retrospective Studies
Glioblastoma IDH-wildtype Spinal cord metastasis Survival

Journal

Journal of neuro-oncology
ISSN: 1573-7373
Titre abrégé: J Neurooncol
Pays: United States
ID NLM: 8309335

Informations de publication

Date de publication:
Apr 2023
Historique:
received: 21 01 2023
accepted: 13 03 2023
medline: 10 5 2023
pubmed: 30 3 2023
entrez: 29 3 2023
Statut: ppublish

Résumé

Spinal cord metastasis arising from an intracranial glioblastoma is a rare and late event during the natural course of the disease. These pathological entities remain poorly characterized. This study aimed to identify and investigate the timeline, clinical and imaging findings, and prognostic factors of spinal cord metastasis from a glioblastoma. Consecutive histopathological cases of spinal cord metastasis from glioblastomas in adults entered in the French nationwide database between January 2004 and 2016 were screened. Overall, 14 adult patients with a brain glioblastoma (median age 55.2 years) and harboring a spinal cord metastasis were included. The median overall survival as 16.0 months (range, 9.8-22.2). The median spinal cord Metastasis Free Survival (time interval between the glioblastoma diagnosis and the spinal cord metastasis diagnosis) was 13.6 months (range, 0.0-27.9). The occurrence of a spinal cord metastasis diagnosis greatly impacted neurological status: 57.2% of patients were not ambulatory, which contributed to dramatically decreased Karnofsky Performance Status (KPS) scores (12/14, 85.7% with a KPS score ≤ 70). The median overall survival following spinal cord metastasis was 3.3 months (range, 1.3-5.3). Patients with a cerebral ventricle effraction during the initial brain surgery had a shorter spinal cord Metastasis Free Survival (6.6 vs 18.3 months, p = 0.023). Out of the 14 patients, eleven (78.6%) had a brain IDH-wildtype glioblastoma. Spinal cord metastasis from a brain IDH-wildtype glioblastoma has a poor prognosis. Spinal MRI can be proposed during the follow-up of glioblastoma patients especially those who have benefited from cerebral surgical resection with opening of the cerebral ventricles.

Sections du résumé

BACKGROUND AND OBJECTIVES OBJECTIVE
Spinal cord metastasis arising from an intracranial glioblastoma is a rare and late event during the natural course of the disease. These pathological entities remain poorly characterized. This study aimed to identify and investigate the timeline, clinical and imaging findings, and prognostic factors of spinal cord metastasis from a glioblastoma.
METHODS METHODS
Consecutive histopathological cases of spinal cord metastasis from glioblastomas in adults entered in the French nationwide database between January 2004 and 2016 were screened.
RESULTS RESULTS
Overall, 14 adult patients with a brain glioblastoma (median age 55.2 years) and harboring a spinal cord metastasis were included. The median overall survival as 16.0 months (range, 9.8-22.2). The median spinal cord Metastasis Free Survival (time interval between the glioblastoma diagnosis and the spinal cord metastasis diagnosis) was 13.6 months (range, 0.0-27.9). The occurrence of a spinal cord metastasis diagnosis greatly impacted neurological status: 57.2% of patients were not ambulatory, which contributed to dramatically decreased Karnofsky Performance Status (KPS) scores (12/14, 85.7% with a KPS score ≤ 70). The median overall survival following spinal cord metastasis was 3.3 months (range, 1.3-5.3). Patients with a cerebral ventricle effraction during the initial brain surgery had a shorter spinal cord Metastasis Free Survival (6.6 vs 18.3 months, p = 0.023). Out of the 14 patients, eleven (78.6%) had a brain IDH-wildtype glioblastoma.
CONCLUSIONS CONCLUSIONS
Spinal cord metastasis from a brain IDH-wildtype glioblastoma has a poor prognosis. Spinal MRI can be proposed during the follow-up of glioblastoma patients especially those who have benefited from cerebral surgical resection with opening of the cerebral ventricles.

Identifiants

DOI: 10.1007/s11060-023-04298-3 PMID: 36991306
pubmed: 36991306
doi: 10.1007/s11060-023-04298-3
pii: 10.1007/s11060-023-04298-3
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

373-382

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

Aymeric Amelot (A)

Department of Neurosurgery, CHRU de Tours, Tours, France. aymmed@hotmail.fr.
Service de Neurochirurgie, CHRU Bretonneau, 2 Boulevard Tonnellé, Tours Cedex 9, 37044, Tours, France. aymmed@hotmail.fr.

Louis-Marie Terrier (LM)

Department of Neurosurgery, Clairval Private Hospital, Ramsay Generale de Sante, Marseille, France.

Gabrielle Cognacq (G)

University of Oxford, John Radcliffe HospitalHeadley Way, Headington, Oxford, OX3 9DU, Oxfordshire, United Kingdom.

Vincent Jecko (V)

Department of Neurosurgery A, CHU Pellegrin, Bordeaux, France.

Benoit Marlier (B)

Department of Neurosurgery, CHU de Reims, Reims, France.

Romuald Seizeur (R)

Department of Neurosurgery, CHU de La Cavale Blanche, Brest, France.

Evelyne Emery (E)

Department of Neurosurgery, CHU de Caen, Caen, France.

Luc Bauchet (L)

Department of Neurosurgery, Hôpital Saint Eloi - Gui de Chauliac, Montpellier, France.

Vincent Roualdes (V)

Department of Neurosurgery, CHU Laennec, Nantes, France.

Jimmy Voirin (J)

Department of Neurosurgery, Pasteur Hospital, HCC, Colmar, France.

Christophe Joubert (C)

Department of Neurosurgery, HIA St Anne, Toulon, France.

Emmanuel Mandonnet (E)

Department of Neurosurgery, Lariboisière, AP-HP, Paris, France.

Leslie Lemnos (L)

Department of Neurosurgery, CHU Dupuytren, Limoges, France.

Bertrand Mathon (B)

Department of Neurosurgery, CHU Pitié-Salpêtrière, AP-HP, Sorbonne Université, Paris, France.

Pierre-Jean Le Reste (PJ)

Department of Neurosurgery, CHU Pontchaillou, Rennes, France.

Andres Coca (A)

Department of Neurosurgery, CHU Strasbourg, Strasbourg, France.

Antoine Petit (A)

Department of Neurosurgery, CHU Jean-Minjoz, Besançon, France.

Valérie Rigau (V)

Department of Neuropathology, CHU Gui de Chauliac, Montpellier, France.

Karima Mokhtari (K)

Department of Neuropathology, Pitié-Salpêtrière, AP-HP, Paris, France.

Audrey Rousseau (A)

Department of Pathology, CHU d'Angers, Angers, France.

Philippe Metellus (P)

Department of Neurosurgery, Clairval Private Hospital, Ramsay Generale de Sante, Marseille, France.

Dominique Figarella-Branger (D)

Department of Neuropathology, La Timone, AP-HM, Marseille, France.

Guillaume Gauchotte (G)

Department of Pathology, CHU Nancy, Nancy, France.

Kaissar Farah (K)

Department of Neurosurgery, CHU La Timone, Marseille, France.

Johan Pallud (J)

Department of Neurosurgery, GHU-Paris Psychiatrie Et Neurosciences, Hôpital Sainte-Anne, Paris, France.

Ilyess Zemmoura (I)

Department of Neurosurgery, CHRU de Tours, Tours, France.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Natural history of spinal cord metastasis from...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Natural history of spinal cord metastasis from...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Natural history of spinal cord metastasis from...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › Glioblastome › Natural history of spinal cord metastasis from...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs de la moelle épinière › Natural history of spinal cord metastasis from...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Natural history of spinal cord metastasis from...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Natural history of spinal cord metastasis from...
questionsmedicales.fr › Diagnostic › Pronostic › Natural history of spinal cord metastasis from...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Natural history of spinal cord metastasis from...