Mapping the dynamic genetic regulatory architecture of

Journal

medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986

Informations de publication

Date de publication:
20 Mar 2023
Historique:
pubmed: 31 3 2023
medline: 31 3 2023
entrez: 30 3 2023
Statut: epublish

Résumé

The human leukocyte antigen (HLA) locus plays a critical role in complex traits spanning autoimmune and infectious diseases, transplantation, and cancer. While coding variation in

Identifiants

DOI: 10.1101/2023.03.14.23287257 PMID: 36993194 PMC: PMC10055604
pubmed: 36993194
doi: 10.1101/2023.03.14.23287257
pmc: PMC10055604
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK043351
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG002295
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR007530
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM144273
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR063759
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG012009
Pays : United States
Organisme : NIAID NIH HHS
ID : F30 AI172238
Pays : United States
Organisme : NIAID NIH HHS
ID : F30 AI157385
Pays : United States
Organisme : NIAMS NIH HHS
ID : UC2 AR081023
Pays : United States

Commentaires et corrections

Type : UpdateIn

Auteurs

Joyce B Kang (JB)

Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Amber Z Shen (AZ)

Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Saori Sakaue (S)

Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Yang Luo (Y)

Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.

Saisriram Gurajala (S)

Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Aparna Nathan (A)

Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Laurie Rumker (L)

Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Vitor R C Aguiar (VRC)

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Cristian Valencia (C)

Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Kaitlyn Lagattuta (K)

Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Fan Zhang (F)

Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Division of Rheumatology and the Center for Health Artificial Intelligence, University of Colorado School of Medicine, Aurora, CO, USA.

Anna Helena Jonsson (AH)

Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Seyhan Yazar (S)

Garvan Institute of Medical Research, Sydney, NSW, Australia.

Jose Alquicira-Hernandez (J)

Garvan Institute of Medical Research, Sydney, NSW, Australia.

Hamed Khalili (H)

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Ashwin N Ananthakrishnan (AN)

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Karthik Jagadeesh (K)

Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Kushal Dey (K)

Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Mark J Daly (MJ)

Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
The Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Ramnik J Xavier (RJ)

Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Laura T Donlin (LT)

Hospital for Special Surgery, New York, NY, USA.
Weill Cornell Medicine, New York, NY, USA.

Jennifer H Anolik (JH)

Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA.

Joseph E Powell (JE)

Garvan Institute of Medical Research, Sydney, NSW, Australia.

Deepak A Rao (DA)

Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Michael B Brenner (MB)

Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Maria Gutierrez-Arcelus (M)

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Soumya Raychaudhuri (S)

Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Classifications MeSH