Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
25 Mar 2023
25 Mar 2023
Historique:
medline:
31
3
2023
entrez:
30
3
2023
pubmed:
31
3
2023
Statut:
epublish
Résumé
Human immunodeficiency virus (HIV) and other lentiviruses adapt to new hosts by evolving to evade host-specific innate immune proteins that differ in sequence and often viral recognition between host species. Understanding how these host antiviral proteins, called restriction factors, constrain lentivirus replication and transmission is key to understanding the emergence of pandemic viruses like HIV-1. Human TRIM34, a paralogue of the well-characterized lentiviral restriction factor TRIM5α, was previously identified by our lab via CRISPR-Cas9 screening as a restriction factor of certain HIV and SIV capsids. Here, we show that diverse primate TRIM34 orthologues from non-human primates can restrict a range of Simian Immunodeficiency Virus (SIV) capsids including SIV
Identifiants
pubmed: 36993223
doi: 10.1101/2023.03.24.534139
pmc: PMC10055373
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIDA NIH HHS
ID : DP1 DA051110
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA015704
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI147877
Pays : United States
Organisme : NIAID NIH HHS
ID : U54 AI170856
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI083203
Pays : United States
Commentaires et corrections
Type : UpdateIn
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