Insufficient evidence for natural selection associated with the Black Death.


Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
15 Mar 2023
Historique:
pubmed: 31 3 2023
medline: 31 3 2023
entrez: 30 3 2023
Statut: epublish

Résumé

Klunk et al. analyzed ancient DNA data from individuals in London and Denmark before, during and after the Black Death [1], and argued that allele frequency changes at immune genes were too large to be produced by random genetic drift and thus must reflect natural selection. They also identified four specific variants that they claimed show evidence of selection including at

Identifiants

pubmed: 36993413
doi: 10.1101/2023.03.14.532615
pmc: PMC10055098
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM133708
Pays : United States

Auteurs

Alison R Barton (AR)

Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

Cindy G Santander (CG)

Department of Biology, University of Copenhagen, Copenhagen, DK-2200, Denmark.

Pontus Skoglund (P)

Ancient Genomics Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

Ida Moltke (I)

Department of Biology, University of Copenhagen, Copenhagen, DK-2200, Denmark.

David Reich (D)

Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.

Iain Mathieson (I)

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA 19104, USA.

Classifications MeSH