Esm-1 mediates transcriptional polarization associated with diabetic kidney disease.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
02 Mar 2023
02 Mar 2023
Historique:
medline:
31
3
2023
entrez:
30
3
2023
pubmed:
31
3
2023
Statut:
epublish
Résumé
Esm-1, endothelial cell-specific molecule-1, is a susceptibility gene for diabetic kidney disease (DKD) and is a cytokine- and glucose-regulated, secreted proteoglycan, that is notably expressed in kidney and attenuates inflammation and albuminuria. We utilized publicly available single-cell RNA sequencing data to explore the characteristics of In both mice and humans, A comprehensive analysis of single cell and bulk transcriptomes demonstrates that diabetes correlates with lower
Sections du résumé
Background
UNASSIGNED
Esm-1, endothelial cell-specific molecule-1, is a susceptibility gene for diabetic kidney disease (DKD) and is a cytokine- and glucose-regulated, secreted proteoglycan, that is notably expressed in kidney and attenuates inflammation and albuminuria.
Methods
UNASSIGNED
We utilized publicly available single-cell RNA sequencing data to explore the characteristics of
Results
UNASSIGNED
In both mice and humans,
Conclusions
UNASSIGNED
A comprehensive analysis of single cell and bulk transcriptomes demonstrates that diabetes correlates with lower
Identifiants
pubmed: 36993439
doi: 10.1101/2023.03.01.530562
pmc: PMC10054923
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK091565
Pays : United States