Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade.

The mitochondrial genome encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutation in the cancer genome, with truncating mutations in respiratory complex I genes being most over-represented

Déclaration de conflit d'intérêts

Competing interests M.M., E.R. and P.A.G. are named inventors on patent applications resulting from this work filed by Cancer Research Horizons. P.A.G is a shareholder, and has been a consultant and Scientific Advisory Board member to Pretzel Therapeutics Inc.