Transitions between cognitive topographies: contributions of network structure, neuromodulation, and disease.

Patterns of neural activity underlie human cognition. Transitions between these patterns are orchestrated by the brain's network architecture. What are the mechanisms linking network structure to cognitively relevant activation patterns? Here we implement principles of network control to investigate how the architecture of the human connectome shapes transitions between 123 experimentally defined cognitive activation maps (cognitive topographies) from the NeuroSynth meta-analytic engine. We also systematically incorporate neurotransmitter receptor density maps (18 receptors and transporters) and disease-related cortical abnormality maps (11 neurodegenerative, psychiatric and neurodevelopmental diseases;

Déclaration de conflit d'intérêts

Conflicts of interest D.B. is shareholder and advisory board member of MindState Design Labs, USA. All other authors have no conflicts of interest to report.