Benchmarking of deep neural networks for predicting personal gene expression from DNA sequence highlights shortcomings.


Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
28 Sep 2023
Historique:
pubmed: 31 3 2023
medline: 31 3 2023
entrez: 30 3 2023
Statut: epublish

Résumé

Deep learning methods have recently become the state-of-the-art in a variety of regulatory genomic tasks

Identifiants

pubmed: 36993652
doi: 10.1101/2023.03.16.532969
pmc: PMC10055057
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIA NIH HHS
ID : P30 AG072975
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG046152
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG061356
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG017917
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057911
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010161
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG036836
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG015819
Pays : United States

Commentaires et corrections

Type : UpdateIn

Déclaration de conflit d'intérêts

Competing Interests Statement The authors declare no competing interests.

Auteurs

Alexander Sasse (A)

Paul G. Allen School of Computer Science and Engineering, University of Washington, WA, USA, 98195.

Bernard Ng (B)

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA, 60612.

Anna E Spiro (AE)

Paul G. Allen School of Computer Science and Engineering, University of Washington, WA, USA, 98195.

Shinya Tasaki (S)

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA, 60612.

David A Bennett (DA)

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA, 60612.

Christopher Gaiteri (C)

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA, 60612.
Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA 13210.

Philip L De Jager (PL)

Center for Translational & Computational Neuroimmunology, Department of Neurology, and the Taub Institute for the Study of Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA, 10032.

Maria Chikina (M)

Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA, 15260.

Sara Mostafavi (S)

Paul G. Allen School of Computer Science and Engineering, University of Washington, WA, USA, 98195.
Canadian Institute for Advanced Research, Toronto, ON, Canada, MG5 1ZB.

Classifications MeSH