Venous dysfunction in obstructive hypertrophic cardiomyopathies: Results from the "HCM-Vein" pilot study.
Endothelial dysfunction
Hypertrophic cardiomyopathy
Left ventricular outflow-tract obstruction
Venous return
Journal
International journal of cardiology. Heart & vasculature
ISSN: 2352-9067
Titre abrégé: Int J Cardiol Heart Vasc
Pays: Ireland
ID NLM: 101649525
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
08
02
2023
revised:
08
03
2023
accepted:
15
03
2023
medline:
31
3
2023
entrez:
30
3
2023
pubmed:
31
3
2023
Statut:
epublish
Résumé
Hypertrophic cardiomyopathies (HCM) can be complicated by left ventricular outflow-tract obstruction (LVOTO) responsible for disabling exercise symptoms, a phenomenon influenced by hemodynamic factors including venous return. We aimed to evaluate venous dysfunction in obstructive HCM patients compared to healthy controls, and to investigate the relationship between venous dysfunction parameters and LVOTO in HCM. This is a clinical, monocentric, prospective, pilot study, in a tertiary care center. We investigated venous function using venous air plethysmography, and endothelial function. Among the 30 symptomatic obstructive HCM patients, 30% (n = 9) presented abnormal venous residual volume fraction (RVFv) which translates in elevated ambulatory venous pressure In this pilot monocentric study, venous insufficiency was observed in about 30% of symptomatic obstructive HCM patients. Patients with venous insufficiency had more frequently a smaller LV cavity volume. Due to the small sample size, this study is only hypothesis-generating, and further investigations are needed.
Sections du résumé
Background
UNASSIGNED
Hypertrophic cardiomyopathies (HCM) can be complicated by left ventricular outflow-tract obstruction (LVOTO) responsible for disabling exercise symptoms, a phenomenon influenced by hemodynamic factors including venous return.
Methods
UNASSIGNED
We aimed to evaluate venous dysfunction in obstructive HCM patients compared to healthy controls, and to investigate the relationship between venous dysfunction parameters and LVOTO in HCM. This is a clinical, monocentric, prospective, pilot study, in a tertiary care center. We investigated venous function using venous air plethysmography, and endothelial function.
Results
UNASSIGNED
Among the 30 symptomatic obstructive HCM patients, 30% (n = 9) presented abnormal venous residual volume fraction (RVFv) which translates in elevated ambulatory venous pressure
Conclusions
UNASSIGNED
In this pilot monocentric study, venous insufficiency was observed in about 30% of symptomatic obstructive HCM patients. Patients with venous insufficiency had more frequently a smaller LV cavity volume. Due to the small sample size, this study is only hypothesis-generating, and further investigations are needed.
Identifiants
pubmed: 36993942
doi: 10.1016/j.ijcha.2023.101198
pii: S2352-9067(23)00029-5
pmc: PMC10040706
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101198Informations de copyright
© 2023 The Authors. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: This study was partially granted by Amicus Therapeutics.
Références
Circulation. 2006 Nov 21;114(21):2232-9
pubmed: 17088454
J Vasc Surg. 1997 Aug;26(2):265-73
pubmed: 9279314
Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H2-12
pubmed: 20952670
Am J Cardiol. 2010 Jan 1;105(1):112-5
pubmed: 20102901
J Am Coll Cardiol. 2006 Mar 21;47(6):1175-81
pubmed: 16545649
Int Angiol. 1995 Mar;14(1):45-52
pubmed: 7658103
Heart. 2008 Jun;94(6):e21
pubmed: 17923461
Eur Heart J Cardiovasc Imaging. 2015 Mar;16(3):233-70
pubmed: 25712077
Eur Heart J Cardiovasc Imaging. 2018 Jan 1;19(1):31-38
pubmed: 28329285
N Engl J Med. 2006 Aug 3;355(5):488-98
pubmed: 16885552
J Am Soc Echocardiogr. 2010 Jul;23(7):685-713; quiz 786-8
pubmed: 20620859
Eur Heart J. 2014 Oct 14;35(39):2733-79
pubmed: 25173338
J Am Coll Cardiol. 2013 Aug 27;62(9):842-50
pubmed: 23810875
Acta Cardiol. 2017 Jun;72(3):265-266
pubmed: 28636508
J Am Soc Echocardiogr. 2015 Feb;28(2):194-203
pubmed: 25459499
Vasc Med. 1997;2(3):203-13
pubmed: 9546969
J Am Coll Cardiol. 2020 Dec 22;76(25):3022-3055
pubmed: 33229115
Pharmacol Rep. 2007 Nov-Dec;59(6):715-20
pubmed: 18195461
Arch Cardiovasc Dis. 2016 Mar;109(3):223-5
pubmed: 26898633