Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil.
Journal
Revista da Sociedade Brasileira de Medicina Tropical
ISSN: 1678-9849
Titre abrégé: Rev Soc Bras Med Trop
Pays: Brazil
ID NLM: 7507456
Informations de publication
Date de publication:
2023
2023
Historique:
received:
15
12
2022
accepted:
02
02
2023
medline:
3
4
2023
entrez:
30
3
2023
pubmed:
31
3
2023
Statut:
epublish
Résumé
Brazil has the second largest number of leprosy cases worldwide, and the state of São Paulo has been considered non-endemic since 2006. We analyzed 16 variable number tandem repeats loci and three single nucleotide polymorphisms loci of Mycobacterium leprae (M. leprae) in 125 clinical isolates from patients in different municipalities in the state. The clustering pattern of M. leprae indicated that the transmission of leprosy persisted in the state and included scenarios of intra-extra-familial transmission in areas with low endemicity. A significantly active circulation of M. leprae was observed. Therefore, surveillance and control measures must be implemented.
Sections du résumé
BACKGROUND
BACKGROUND
Brazil has the second largest number of leprosy cases worldwide, and the state of São Paulo has been considered non-endemic since 2006.
METHODS
METHODS
We analyzed 16 variable number tandem repeats loci and three single nucleotide polymorphisms loci of Mycobacterium leprae (M. leprae) in 125 clinical isolates from patients in different municipalities in the state.
RESULTS
RESULTS
The clustering pattern of M. leprae indicated that the transmission of leprosy persisted in the state and included scenarios of intra-extra-familial transmission in areas with low endemicity.
CONCLUSIONS
CONCLUSIONS
A significantly active circulation of M. leprae was observed. Therefore, surveillance and control measures must be implemented.
Identifiants
pubmed: 36995787
pii: S0037-86822023000100607
doi: 10.1590/0037-8682-0612-2022
pmc: PMC10042472
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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