Design, Synthesis, and Cytotoxic Activities of Indole and Indazole-Based Stilbenes.
cytotoxicity
indazole
indole
stilbene
structure-activity relationship
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
12
03
2023
accepted:
30
03
2023
medline:
24
5
2023
pubmed:
31
3
2023
entrez:
30
3
2023
Statut:
ppublish
Résumé
To develop new highly effective anticancer agents derived from naturally occurring stilbene scaffold, in total of 24 indole and indazole-based stilbenes including 17 new compounds were designed according to molecular hybridization strategy and synthesized via Witting reaction. The cytotoxic screening results against human tumor cell lines (K562 cells and MDA-MB-231 cells) showed that indole and indazole-based stilbenes are of great interest for developing anticancer agents as eight derivatives possessed strong antiproliferative activities with IC
Identifiants
pubmed: 36996024
doi: 10.1002/cbdv.202300368
doi:
Substances chimiques
Stilbenes
0
Indazoles
0
Antineoplastic Agents
0
Indoles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202300368Subventions
Organisme : NSFC
ID : U2006204
Organisme : NSFC-TRF
ID : 2181101213
Organisme : National Key Research and Development Program of China
ID : 2018YFC0310903
Organisme : Ocean University of China
Informations de copyright
© 2023 Wiley-VHCA AG, Zurich, Switzerland.
Références
S. Zhao, J. Liu, Z. Lv, G. Zhang, Z. Xu, Eur. J. Med. Chem. 2023, 251, 115254.
J. Imeri, C. Desterke, P. Marcoux, G. Telliam, S. Sanekli, S. Barreau, Y. Erbilgin, T. Latsis, P. Hugues, N. Sorel, E. Cayssials, J. C. Chomel, A. B. Griscelli, A. G. Turhan, Cells 2023, 12, 598.
K. Barzaman, J. Karami, Z. Zarei, A. Hosseinzadeh, M. H. Kazemi, S. M. Kalbolandi, E. Safari, L. Farahmand, Int. Immunopharmacol. 2020, 84, 106535.
X. C. Jiang, F. H. Tu, L. Y. Wei, B. Z. Wang, H. Yuan, J. M. Yuan, Y. Rao, S. L. Huang, Q. J. Li, T. M. Ou, H. G. Wang, J. H. Tan, S. B. Chen, Z. S. Huang, J. Med. Chem. 2022, 65, 12346-12366.
D. Ma, P. Liu, C. Hu, Z. Zhou, P. Wang, Y. Wang, Y. Zhang, Y. Ran, P. Li, J. Zhao, J. Wang, C. Zhang, L. Tang, Oncogene 2023, 42, 124-137.
F. I. Saldívar-González, V. D. Aldas-Bulos, J. L. Medina-Franco, F. Plisson, Chem. Sci. 2022, 13, 1526-1546.
P. Pecyna, J. Wargula, M. Murias, M. Kucinska, Biomol. Eng. 2020, 10, 1111.
Y. C. Koh, C. T. Ho, M. H. Pan, J. Agric. Food Chem. 2021, 69, 10036-10057.
T. Teka, L. Zhang, X. Ge, Y. Li, L. Han, X. Yan, Phytochemistry 2022, 197, 113128.
D. V. Patel, N. R. Patel, A. M. Kanhed, D. M. Teli, K. B. Patel, P. D. Joshi, S. P. Patel, P. M. Gandhi, B. N. Chaudhary, N. K. Prajapati, K. V. Patel, M. R. Yadav, Bioorg. Chem. 2020, 101, 103977.
Y. Z. Zhu, K. Chen, Y. L. Chen, C. Zhang, Y. Y. Xie, R. C. Hider, T. Zhou, Food Chem. 2022, 385, 132730.
X. Lin, Y. Li, W. Zhong, T. Hong, L. Li, S. Song, D. He, J. Agric. Food Chem. 2021, 69, 9520-9528.
R. A. Mekheimer, S. M. R. Allam, M. A. A. Sheikh, M. S. Moustafa, S. M. A. Mousawi, Y. A. Mostafa, B. G. M. Youssif, H. A. M. Gomaa, A. M. Hayallah, M. Abdelaziz, K. U. Sadek, Bioorg. Chem. 2022, 121, 105693.
H. Zhou, H. Zhu, Y. Zha, J. Xu, T. Wang, S. Xu, Fitoterapia 2022, 160, 105222.
S. Dadashpour, S. Emami, Eur. J. Med. Chem. 2018, 150, 9-29.
J. Dong, Q. Zhang, Z. Wang, G. Huang, S. Li, ChemMedChem 2018, 13, 1490-1507.
J. Shearer, J. L. Castro, A. D. G. Lawson, M. MacCoss, R. D. Taylor, J. Med. Chem. 2022, 65, 8699-8712.
D. Schmidt, T. Rodat, L. Heintze, J. Weber, R. Horbert, U. Girreser, T. Raeker, L. Bußmann, M. Kriegs, B. Hartke, C. Peifer, ChemMedChem 2018, 13, 2415-2426.
Y. Jia, X. Wen, Y. Gong, X. Wang, Eur. J. Med. Chem. 2020, 200, 112359.