Genomic investigations of unexplained acute hepatitis in children.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
25
07
2022
accepted:
23
03
2023
medline:
19
5
2023
pubmed:
31
3
2023
entrez:
30
3
2023
Statut:
ppublish
Résumé
Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK
Identifiants
pubmed: 36996872
doi: 10.1038/s41586-023-06003-w
pii: 10.1038/s41586-023-06003-w
pmc: PMC10170458
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
564-573Subventions
Organisme : Medical Research Council
ID : MC_UU_12014/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00034/6
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206478
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206478/Z/17/Z
Pays : United Kingdom
Investigateurs
Evangelos Bellos
(E)
Claire Broderick
(C)
Samuel Channon-Wells
(S)
Tisham De
(T)
Giselle D'Souza
(G)
Leire Estramiana Elorrieta
(LE)
Diego Estrada-Rivadeneyra
(D)
Rachel Galassini
(R)
Dominic Habgood-Coote
(D)
Shea Hamilton
(S)
Heather Jackson
(H)
James Kavanagh
(J)
Mahdi Moradi Marjaneh
(MM)
Stephanie Menikou
(S)
Samuel Nichols
(S)
Ruud Nijman
(R)
Harsita Patel
(H)
Ivana Pennisi
(I)
Oliver Powell
(O)
Ruth Reid
(R)
Ortensia Vito
(O)
Elizabeth Whittaker
(E)
Clare Wilson
(C)
Rebecca Womersley
(R)
Amina Abdulla
(A)
Sarah Darnell
(S)
Sobia Mustafa
(S)
Pantelis Georgiou
(P)
Jesus-Rodriguez Manzano
(JR)
Nicolas Moser
(N)
Michael Carter
(M)
Shane Tibby
(S)
Jonathan Cohen
(J)
Francesca Davis
(F)
Julia Kenny
(J)
Paul Wellman
(P)
Marie White
(M)
Matthew Fish
(M)
Aislinn Jennings
(A)
None Shankar-Hari
Katy Fidler
(K)
Dan Agranoff
(D)
Vivien Richmond
(V)
Matthew Seal
(M)
Saul Faust
(S)
Dan Owen
(D)
Ruth Ensom
(R)
Sarah McKay
(S)
Diana Mondo
(D)
Mariya Shaji
(M)
Rachel Schranz
(R)
Prita Rughnani
(P)
Amutha Anpananthar
(A)
Susan Liebeschuetz
(S)
Anna Riddell
(A)
Nosheen Khalid
(N)
Ivone Lancoma Malcolm
(IL)
Teresa Simagan
(T)
Mark Peters
(M)
Alasdair Bamford
(A)
Nazima Pathan
(N)
Esther Daubney
(E)
Deborah White
(D)
Melissa Heightman
(M)
Sarah Eisen
(S)
Terry Segal
(T)
Lucy Wellings
(L)
Simon B Drysdale
(SB)
Nicole Branch
(N)
Lisa Hamzah
(L)
Heather Jarman
(H)
Maggie Nyirenda
(M)
Lisa Capozzi
(L)
Emma Gardiner
(E)
Robert Moots
(R)
Magda Nasher
(M)
Anita Hanson
(A)
Michelle Linforth
(M)
Sean O'Riordan
(S)
Donna Ellis
(D)
Akash Deep
(A)
Ivan Caro
(I)
Fiona Shackley
(F)
Arianna Bellini
(A)
Stuart Gormley
(S)
Samira Neshat
(S)
Barnaby J Scholefield
(BJ)
Ceri Robbins
(C)
Helen Winmill
(H)
Stéphane C Paulus
(SC)
Andrew J Pollard
(AJ)
Sarah Hopton
(S)
Danielle Miller
(D)
Zoe Oliver
(Z)
Sally Beer
(S)
Bryony Ward
(B)
Shrijana Shrestha
(S)
Meeru Gurung
(M)
Puja Amatya
(P)
Bhishma Pokhrel
(B)
Sanjeev Man Bijukchhe
(SM)
Tim Lubinda
(T)
Sarah Kelly
(S)
Peter O'Reilly
(P)
Federico Martinón-Torres
(F)
Antonio Salas
(A)
Fernando Álvez González
(FÁ)
Xabier Bello
(X)
Mirian Ben García
(MB)
Sandra Carnota
(S)
Miriam Cebey-López
(M)
María José Curras-Tuala
(MJ)
Carlos Durán Suárez
(CD)
Luisa García Vicente
(LG)
Alberto Gómez-Carballa
(A)
Jose Gómez Rial
(JG)
Pilar Leboráns Iglesias
(PL)
Nazareth Martinón-Torres
(N)
José María Martinón Sánchez
(JMM)
Belén Mosquera Pérez
(BM)
Jacobo Pardo-Seco
(J)
Lidia Piñeiro Rodríguez
(LP)
Sara Pischedda
(S)
Sara Rey Vázquez
(SR)
Irene Rivero Calle
(IR)
Carmen Rodríguez-Tenreiro
(C)
Lorenzo Redondo-Collazo
(L)
Miguel Sadiki Ora
(MS)
Sonia Serén Fernández
(SS)
Cristina Serén Trasorras
(CS)
Marisol Vilas Iglesias
(MV)
Enitan D Carrol
(ED)
Elizabeth Cocklin
(E)
Aakash Khanijau
(A)
Rebecca Lenihan
(R)
Nadia Lewis-Burke
(N)
Karen Newal
(K)
Sam Romaine
(S)
Maria Tsolia
(M)
Irini Eleftheriou
(I)
Nikos Spyridis
(N)
Maria Tambouratzi
(M)
Despoina Maritsi
(D)
Antonios Marmarinos
(A)
Marietta Xagorari
(M)
Lourida Panagiota
(L)
Pefanis Aggelos
(P)
Akinosoglou Karolina
(A)
Gogos Charalambos
(G)
Maragos Markos
(M)
Voulgarelis Michalis
(V)
Stergiou Ioanna
(S)
Marieke Emonts
(M)
Emma Lim
(E)
John Isaacs
(J)
Kathryn Bell
(K)
Stephen Crulley
(S)
Daniel Fabian
(D)
Evelyn Thomson
(E)
Caroline Miller
(C)
Ashley Bell
(A)
Fabian J S van der Velden
(FJS)
Geoff Shenton
(G)
Ashley Price
(A)
Owen Treloar
(O)
Daisy Thomas
(D)
Pablo Rojo
(P)
Cristina Epalza
(C)
Serena Villaverde
(S)
Sonia Márquez
(S)
Manuel Gijón
(M)
Fátima Machín
(F)
Laura Cabello
(L)
Irene Hernández
(I)
Lourdes Gutiérrez
(L)
Ángela Manzanares
(Á)
Taco Kuijpers
(T)
Martijn van de Kuip
(M)
Marceline van Furth
(M)
Merlijn van den Berg
(M)
Giske Biesbroek
(G)
Floris Verkuil
(F)
Carlijn van der Zee
(C)
Dasja Pajkrt
(D)
Michael Boele van Hensbroek
(MB)
Dieneke Schonenberg
(D)
Mariken Gruppen
(M)
Sietse Nagelkerke
(S)
Machiel H Jansen
(MH)
Ines Goetschalckx
(I)
Lorenza Romani
(L)
Maia De Luca
(M)
Sara Chiurchiù
(S)
Martina Di Giuseppe
(MD)
Clementien L Vermont
(CL)
Henriëtte A Moll
(HA)
Dorine M Borensztajn
(DM)
Nienke N Hagedoorn
(NN)
Chantal Tan
(C)
Joany Zachariasse
(J)
W Dik
(W)
Ching-Fen Shen
(CF)
Dace Zavadska
(D)
Sniedze Laivacuma
(S)
Aleksandra Rudzate
(A)
Diana Stoldere
(D)
Arta Barzdina
(A)
Elza Barzdina
(E)
Sniedze Laivacuma
(S)
Monta Madelane
(M)
Dagne Gravele
(D)
Dace Svile
(D)
Romain Basmaci
(R)
Noémie Lachaume
(N)
Pauline Bories
(P)
Raja Ben Tkhayat
(RB)
Laura Chériaux
(L)
Juraté Davoust
(J)
Kim-Thanh Ong
(KT)
Marie Cotillon
(M)
Thibault de Groc
(T)
Sébastien Le
(S)
Nathalie Vergnault
(N)
Hélène Sée
(H)
Laure Cohen
(L)
Alice de Tugny
(A)
Nevena Danekova
(N)
Marine Mommert-Tripon
(M)
Karen Brengel-Pesce
(K)
Marko Pokorn
(M)
Mojca Kolnik
(M)
Tadej Avcin
(T)
Tanja Avramoska
(T)
Natalija Bahovec
(N)
Petra Bogovic
(P)
Lidija Kitanovski
(L)
Mirijam Nahtigal
(M)
Lea Papst
(L)
Tina Plankar Srovin
(TP)
Franc Strle
(F)
Anja Srpcic
(A)
Katarina Vincek
(K)
Michiel van der Flier
(M)
Wim J E Tissing
(WJE)
Roelie M Wösten-van Asperen
(RM)
Sebastiaan J Vastert
(SJ)
Daniel C Vijlbrief
(DC)
Louis J Bont
(LJ)
Tom F W Wolfs
(TFW)
Coco R Beudeker
(CR)
Philipp Agyeman
(P)
Luregn Schlapbach
(L)
Christoph Aebi
(C)
Mariama Usman
(M)
Stefanie Schlüchter
(S)
Verena Wyss
(V)
Nina Schöbi
(N)
Elisa Zimmermann
(E)
Kathrin Weber
(K)
Eric Giannoni
(E)
Martin Stocker
(M)
Klara M Posfay-Barbe
(KM)
Ulrich Heininger
(U)
Sara Bernhard-Stirnemann
(S)
Anita Niederer-Loher
(A)
Christian Kahlert
(C)
Giancarlo Natalucci
(G)
Christa Relly
(C)
Thomas Riedel
(T)
Christoph Berger
(C)
Jennifer Holden
(J)
Leo Calvo-Bado
(L)
Benjamin Evans
(B)
Jake Stevens
(J)
Peter Matthews
(P)
Kyle Billing
(K)
Werner Zenz
(W)
Alexander Binder
(A)
Benno Kohlmaier
(B)
Daniela S Kohlfürst
(DS)
Nina A Schweintzger
(NA)
Christoph Zurl
(C)
Susanne Hösele
(S)
Manuel Leitner
(M)
Lena Pölz
(L)
Alexandra Rusu
(A)
Glorija Rajic
(G)
Bianca Stoiser
(B)
Martina Strempfl
(M)
Manfred G Sagmeister
(MG)
Sebastian Bauchinger
(S)
Martin Benesch
(M)
Astrid Ceolotto
(A)
Ernst Eber
(E)
Siegfried Gallistl
(S)
Harald Haidl
(H)
Almuthe Hauer
(A)
Christa Hude
(C)
Andreas Kapper
(A)
Markus Keldorfer
(M)
Sabine Löffler
(S)
Tobias Niedrist
(T)
Heidemarie Pilch
(H)
Andreas Pfleger
(A)
Klaus Pfurtscheller
(K)
Siegfried Rödl
(S)
Andrea Skrabl-Baumgartner
(A)
Volker Strenger
(V)
Elmar Wallner
(E)
Dennie Tempel
(D)
Danielle van Keulen
(D)
Annelieke M Strijbosch
(AM)
Maike K Tauchert
(MK)
Ulrich von Both
(U)
Laura Kolberg
(L)
Patricia Schmied
(P)
Irene Alba-Alejandre
(I)
Katharina Danhauser
(K)
Nikolaus Haas
(N)
Florian Hoffmann
(F)
Matthias Griese
(M)
Tobias Feuchtinger
(T)
Sabrina Juranek
(S)
Matthias Kappler
(M)
Eberhard Lurz
(E)
Esther Maier
(E)
Karl Reiter
(K)
Carola Schoen
(C)
Sebastian Schroepf
(S)
Shunmay Yeung
(S)
Manuel Dewez
(M)
David Bath
(D)
Elizabeth Fitchett
(E)
Fiona Cresswell
(F)
Aubrey Cunnington
(A)
Jethro Herberg
(J)
Mysini Kaforou
(M)
Victoria Wright
(V)
Lucas Baumard
(L)
Clive Hoggart
(C)
Sara Hourmat
(S)
Ian Maconochie
(I)
Naomi Lin
(N)
Ivonne Pena Paz
(IP)
Ladan Ali
(L)
Rikke Jorgensen
(R)
Salina Persand
(S)
Molly Stevens
(M)
Eunjung Kim
(E)
Benjamin Pierce
(B)
Julia Dudley
(J)
Emma Tavliavini
(E)
Ching-Chuan Liu
(CC)
Shih-Min Wang
(SM)
Cristina Balo Farto
(CB)
Ruth Barral-Arca
(R)
Maria Barreiro Castro
(MB)
Anda Balode
(A)
Dārta Deksne
(D)
Ilze Grope
(I)
Anija Meiere
(A)
Ieva Nokalna
(I)
Jana Pavare
(J)
Zanda Pucuka
(Z)
Katrina Selecka
(K)
Aleksandra Sidorova
(A)
Urzula Nora Urbane
(UN)
Effua Usuf
(E)
Kalifa Bojang
(K)
Syed M A Zaman
(SMA)
Fatou Secka
(F)
Suzanne Anderson
(S)
Anna RocaIsatou Sarr
(AR)
Momodou Saidykhan
(M)
Saffiatou Darboe
(S)
Samba Ceesay
(S)
Umberto D'alessandro
(U)
Luregn J Schlapbach
(LJ)
Stéphane Paulus
(S)
Rebecca Jennings
(R)
Joanne Johnston
(J)
Simon Leigh
(S)
Karen Newall
(K)
Antonis Marmarinos
(A)
Kelly Syggelou
(K)
Hinrich Baumgart
(H)
Martin Benesch
(M)
Gunther Gores
(G)
Larissa Krenn
(L)
Gudrun Nordberg
(G)
Matthias Sperl
(M)
Laura Stampfer
(L)
Holger Till
(H)
Andreas Trobisch
(A)
Juan Emmanuel Dewez
(JE)
Martin Hibberd
(M)
Alec Miners
(A)
Ruud Nijman
(R)
Catherine Wedderburn
(C)
Anne Meierford
(A)
Baptiste Leurent
(B)
Ronald de Groot
(R)
Michiel van der Flier
(M)
Marien I de Jonge
(MI)
Koen van Aerde
(K)
Wynand Alkema
(W)
Bryan van den Broek
(B)
Jolein Gloerich
(J)
Alain J van Gool
(AJ)
Stefanie Henriet
(S)
Martijn Huijnen
(M)
Ria Philipsen
(R)
Esther Willems
(E)
G P J M Gerrits
(GPJM)
M van Leur
(M)
J Heidema
(J)
L de Haan
(L)
C J Miedema
(CJ)
C Neeleman
(C)
C C Obihara
(CC)
G A Tramper-Stranders
(GA)
Rama Kandasamy
(R)
Stéphane Paulus
(S)
Michael J Carter
(MJ)
Daniel O'Connor
(D)
Sagida Bibi
(S)
Dominic F Kelly
(DF)
Stephen Thorson
(S)
Imran Ansari
(I)
David R Murdoch
(DR)
Lucille Valentine
(L)
Karen Allen
(K)
Adora Chan
(A)
Kirsty Devine
(K)
Sharon King
(S)
Paul McAlinden
(P)
Sam McDonald
(S)
Anne McDonnell
(A)
Ailsa Pickering
(A)
Amanda Wood
(A)
Diane Wallia
(D)
Phil Woodsford
(P)
Frances Baxter
(F)
Mathew Rhodes
(M)
Rachel Agbeko
(R)
Christine Mackerness
(C)
Bryan Baas
(B)
Lieke Kloosterhuis
(L)
Wilma Oosthoek
(W)
Tasnim Arif
(T)
Joshua Bennet
(J)
Kalvin Collings
(K)
Ilona van der Giessen
(I)
Alex Martin
(A)
Aqeela Rashid
(A)
Emily Rowlands
(E)
Gabriella de Vries
(G)
Fabian van der Velden
(F)
Mike Martin
(M)
Ravi Mistry
(R)
Manuela Zwerenz
(M)
Judith Buschbeck
(J)
Christoph Bidlingmaier
(C)
Vera Binder
(V)
Julia Keil
(J)
Georg Muench
(G)
François Mallet
(F)
Alexandre Pachot
(A)
Marine Mommert
(M)
Marko Pokorn
(M)
Petra Prunk
(P)
Veronika Osterman
(V)
Taco Kuijpers
(T)
Ilse Jongerius
(I)
J M van den Berg
(JM)
D Schonenberg
(D)
A M Barendregt
(AM)
D Pajkrt
(D)
M van der Kuip
(M)
A M van Furth
(AM)
Evelien Sprenkeler
(E)
Judith Zandstra
(J)
G van Mierlo
(G)
J Geissler
(J)
Gail Carson
(G)
Peter J M Openshaw
(PJM)
Jake Dunning
(J)
Laura Merson
(L)
Clark D Russell
(CD)
David Dorward
(D)
Richard S Tedder
(RS)
Say Khoo
(S)
Lance C W Turtle
(LCW)
Tom Solomon
(T)
Samreen Ijaz
(S)
Tom Fletcher
(T)
Massimo Palmarini
(M)
Antonia Y W Ho
(AYW)
Nicholas Price
(N)
Thushan de Silva
(T)
Chloe Donohue
(C)
Hayley Hardwick
(H)
Wilna Oosthuyzen
(W)
Lauren Obosi
(L)
Sara Clohisey
(S)
Andrew Law
(A)
Lucy Norris
(L)
Sarah Tait
(S)
Murray Wham
(M)
Richard Clark
(R)
Audrey Coutts
(A)
Lorna Donelly
(L)
Angie Fawkes
(A)
Tammy Gilchrist
(T)
Katarzyna Hafezi
(K)
Louise MacGillivray
(L)
Alan Maclean
(A)
Sarah McCafferty
(S)
Kirstie Morrice
(K)
Lee Murphy
(L)
Nicola Wrobel
(N)
Sarah E McDonald
(SE)
Victoria Shaw
(V)
Jane A Armstrong
(JA)
Lauren Lett
(L)
Paul Henderson
(P)
Louisa Pollock
(L)
Shyla Kishore
(S)
Helen Brotherton
(H)
Lawrence Armstrong
(L)
Andrew Mita
(A)
Anna Dall
(A)
Kristyna Bohmova
(K)
Sheena Logan
(S)
Louise Gannon
(L)
Ken Agwuh
(K)
Srikanth Chukkambotla
(S)
Ingrid DuRand
(I)
Duncan Fullerton
(D)
Sanjeev Garg
(S)
Clive Graham
(C)
Stuart Hartshorn
(S)
Luke Hodgson
(L)
Paul Jennings
(P)
George Koshy
(G)
Tamas Leiner
(T)
James Limb
(J)
Jeff Little
(J)
Elijah Matovu
(E)
Fiona McGill
(F)
Craig Morris
(C)
John Morrice
(J)
David Price
(D)
Henrik Reschreiter
(H)
Tim Reynolds
(T)
Paul Whittaker
(P)
Rachel Tayler
(R)
Clare Irving
(C)
Maxine Ramsay
(M)
Margaret Millar
(M)
Barry Milligan
(B)
Naomy Hickey
(N)
Maggie Connon
(M)
Catriona Ward
(C)
Laura Beveridge
(L)
Susan MacFarlane
(S)
Karen Leitch
(K)
Claire Bell
(C)
Lauren Finlayson
(L)
Joy Dawson
(J)
Janie Candlish
(J)
Laura McGenily
(L)
Tara Roome
(T)
Cynthia Diaba
(C)
Jasmine Player
(J)
Natassia Powell
(N)
Ruth Howman
(R)
Sara Burling
(S)
Sharon Floyd
(S)
Sarah Farmer
(S)
Susie Ferguson
(S)
Susan Hope
(S)
Lucy Rubick
(L)
Rachel Swingler
(R)
Emma Collins
(E)
Collette Spencer
(C)
Amaryl Jones
(A)
Barbara Wilson
(B)
Diane Armstrong
(D)
Mark Birt
(M)
Holly Dickinson
(H)
Rosemary Harper
(R)
Darran Martin
(D)
Amy Roff
(A)
Sarah Mills
(S)
Informations de copyright
© 2023. The Author(s).
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