Platelet function in neonates and children.

Infant, Newborn Adult Child Humans Platelet Aggregation Blood Platelets Hemostasis Platelet Function Tests / methods Blood Coagulation
Blood platelets Child Newborn Platelet activation Platelet aggregation Platelet function tests

Journal

Thrombosis research
ISSN: 1879-2472
Titre abrégé: Thromb Res
Pays: United States
ID NLM: 0326377

Informations de publication

Date de publication:
11 2023
Historique:
received: 02 09 2022
revised: 22 11 2022
accepted: 17 03 2023
medline: 6 11 2023
pubmed: 31 3 2023
entrez: 30 3 2023
Statut: ppublish

Résumé

Platelets are major regulators of haemostasis and coagulation. The primary role of platelets in coagulation is to form a stable clot and stop bleeding. Studies of platelet phenotype and function in neonates and children have been restricted by the large volumes required for many common platelet function tests such as platelet aggregometry. Developmental changes in platelets have not been as well described as developmental changes in plasma coagulation proteins, and overall, platelet phenotype and function in neonates and children has been understudied when compared to adults. Recent developments in more sensitive platelet function testing methods requiring smaller blood volumes such as flow cytometry has enabled recent studies to further investigate platelet phenotype and function in neonates and children. In this review we will provide an overview of recent advances from the past five years in platelets in the context of developmental haemostasis, as well as the role of platelets in neonatal paediatric disease.

Identifiants

DOI: 10.1016/j.thromres.2023.03.005 PMID: 36997443
pubmed: 36997443
pii: S0049-3848(23)00079-8
doi: 10.1016/j.thromres.2023.03.005
pii:
doi:

Types de publication

Review Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

236-246

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Suelyn Van Den Helm (S)

Haematology Research, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia.

Conor McCafferty (C)

Haematology Research, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia.

Natasha Letunica (N)

Haematology Research, Murdoch Children's Research Institute, Melbourne, Australia.

Ka Ying Chau (KY)

Haematology Research, Murdoch Children's Research Institute, Melbourne, Australia.

Paul Monagle (P)

Haematology Research, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia; Department of Clinical Haematology, The Royal Children's Hospital, Melbourne, Australia; Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia.

Vera Ignjatovic (V)

Haematology Research, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia; Johns Hopkins All Children's Hospital, St Petersburg, USA. Electronic address: vignjat1@jhmi.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Platelet function in neonates and children.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Platelet function in neonates and children.
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Platelet function in neonates and children.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Platelet function in neonates and children.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Activation plaquettaire › Agrégation plaquettaire › Platelet function in neonates and children.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Cellules sanguines › Plaquettes › Platelet function in neonates and children.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Platelet function in neonates and children.
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Tests hématologiques › Tests fonctionnels plaquettaires › Platelet function in neonates and children.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Coagulation sanguine › Platelet function in neonates and children.