Differences in clinical and biological factors between patients with PFO-related stroke and patients with PFO and no cerebral vascular events.
PFO (patent foramen ovale)
PFO-associated stroke
Spencer logarithmic scale
primary prevention
thrombophilia
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2023
2023
Historique:
received:
21
11
2022
accepted:
21
02
2023
medline:
1
4
2023
entrez:
31
3
2023
pubmed:
1
4
2023
Statut:
epublish
Résumé
While stroke is one of the most dissected topics in neurology, the primary prevention of PFO-related stroke in young patients is still an unaddressed subject. We present a study concerning clinical, demographic, and laboratory factors associated with stroke and transient ischemic attack in patients with patent foramen ovale (PFO), as well as comparing PFO-patients with and without cerebrovascular ischemic events (CVEs). Consecutive patients with PFO-associated CVEs were included in the study; control group was selected from patients with a PFO and no history of stroke. All participants underwent peripheral routine blood analyses, as well as, on treating physician's recommendations, screening for thrombophilia. Ninety-five patients with CVEs and 41 controls were included. Females had a significantly lower risk of CVEs than males ( There is little difference between patients with PFO with and without CVEs in terms of PFO size and routine laboratory analyses. While still a controversial topic in the specialty literature, classic first-level thrombophilic mutations are not a risk factor for stroke in patients with PFO. Hypertension and male gender were identified as factors associated with a higher risk of stroke in the setting of PFO.
Sections du résumé
Background
UNASSIGNED
While stroke is one of the most dissected topics in neurology, the primary prevention of PFO-related stroke in young patients is still an unaddressed subject. We present a study concerning clinical, demographic, and laboratory factors associated with stroke and transient ischemic attack in patients with patent foramen ovale (PFO), as well as comparing PFO-patients with and without cerebrovascular ischemic events (CVEs).
Patients and methods
UNASSIGNED
Consecutive patients with PFO-associated CVEs were included in the study; control group was selected from patients with a PFO and no history of stroke. All participants underwent peripheral routine blood analyses, as well as, on treating physician's recommendations, screening for thrombophilia.
Results
UNASSIGNED
Ninety-five patients with CVEs and 41 controls were included. Females had a significantly lower risk of CVEs than males (
Discussion and conclusions
UNASSIGNED
There is little difference between patients with PFO with and without CVEs in terms of PFO size and routine laboratory analyses. While still a controversial topic in the specialty literature, classic first-level thrombophilic mutations are not a risk factor for stroke in patients with PFO. Hypertension and male gender were identified as factors associated with a higher risk of stroke in the setting of PFO.
Identifiants
pubmed: 36998773
doi: 10.3389/fneur.2023.1104674
pmc: PMC10043389
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1104674Informations de copyright
Copyright © 2023 Badea, Ribigan, Grecu, Terecoasǎ, Antochi, Bâldea Mihǎilǎ, Tiu and Popescu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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