The Effect of Sub-chronic Linuron Exposure on Thyroid, Liver, and Kidney Function in Male Wistar Rats.
Herbicides
TSH
hypothyroidism
linuron
thyroid disruption
toxicity
Journal
Endocrine, metabolic & immune disorders drug targets
ISSN: 2212-3873
Titre abrégé: Endocr Metab Immune Disord Drug Targets
Pays: United Arab Emirates
ID NLM: 101269157
Informations de publication
Date de publication:
2023
2023
Historique:
received:
27
10
2022
revised:
01
02
2023
accepted:
22
02
2023
pubmed:
1
4
2023
medline:
1
4
2023
entrez:
31
3
2023
Statut:
ppublish
Résumé
Herbicides are routinely used to control noxious plants. Most of these chemicals may cause toxicity and endocrine disruption in humans and wildlife. This study aimed to evaluate the influence of linuron on thyroid hormone levels and some hepatic and renal parameters and organ (thyroid, liver and kidney) structures to assume their toxicity toward experimental animals and to evaluate the endocrine disrupting capacity of this chemical. Two groups (8 rats each) were used for an in vivo study. The lot I served as control. Lot II was exposed to 40 mg/200 mg/day pesticide for 50 days. Changes in hepatic and renal parameters and histological structure were investigated in different treated groups. Data from this study showed that linuron altered thyroid function as evidenced by abnormal TSH, T4, and T3 levels. Furthermore, exposure to linuron induces a significant decrease in body weight and a significant increase in aspartate aminotransferase, alanine transaminase, total bilirubin, uric acid, creatinine, glutathione, and malondialdehyde. Previous data were confirmed through the histopathological examination of different organs. The most used phenylurea herbicide, linuron, disrupted thyroid function at a 40 mg/200 mg/day dose and produced oxidative stress in the liver and kidney in male Wistar rats. The data of this study warrant further investigation.
Sections du résumé
BACKGROUND
BACKGROUND
Herbicides are routinely used to control noxious plants. Most of these chemicals may cause toxicity and endocrine disruption in humans and wildlife.
OBJECTIVE
OBJECTIVE
This study aimed to evaluate the influence of linuron on thyroid hormone levels and some hepatic and renal parameters and organ (thyroid, liver and kidney) structures to assume their toxicity toward experimental animals and to evaluate the endocrine disrupting capacity of this chemical.
METHODS
METHODS
Two groups (8 rats each) were used for an in vivo study. The lot I served as control. Lot II was exposed to 40 mg/200 mg/day pesticide for 50 days. Changes in hepatic and renal parameters and histological structure were investigated in different treated groups.
RESULTS
RESULTS
Data from this study showed that linuron altered thyroid function as evidenced by abnormal TSH, T4, and T3 levels. Furthermore, exposure to linuron induces a significant decrease in body weight and a significant increase in aspartate aminotransferase, alanine transaminase, total bilirubin, uric acid, creatinine, glutathione, and malondialdehyde. Previous data were confirmed through the histopathological examination of different organs.
CONCLUSIONS
CONCLUSIONS
The most used phenylurea herbicide, linuron, disrupted thyroid function at a 40 mg/200 mg/day dose and produced oxidative stress in the liver and kidney in male Wistar rats. The data of this study warrant further investigation.
Identifiants
pubmed: 36999710
pii: EMIDDT-EPUB-130611
doi: 10.2174/1871530323666230331104739
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1621-1627Informations de copyright
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