Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study.
Palliative care
anti-bacterial agents
antimicrobial stewardship
cancer
drug-related side effects and adverse reactions
infections
Journal
Palliative medicine
ISSN: 1477-030X
Titre abrégé: Palliat Med
Pays: England
ID NLM: 8704926
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
medline:
30
5
2023
pubmed:
1
4
2023
entrez:
31
3
2023
Statut:
ppublish
Résumé
Older adults with advanced cancer are exposed to antibiotics but estimates of adverse drug events associated with antibiotic therapy are lacking. Evaluate the association of antibiotic therapy with adverse drug events in older adults with advanced cancer. Cohort study where the exposure was the ratio of days of therapy of an oral or intravenous antibiotic per patient-day and the outcome was an adverse drug event, defined as cardiotoxicity, hepatotoxicity, nephrotoxicity, Patients aged ⩾65 years with solid tumors from a tertiary care center who received palliative chemotherapy ( Mean age was 75 ± 6.6 years, and 52% were female. Common tumors were lung (31%, Antibiotic therapy was independently associated with adverse drug events in hospitalized older adults with advanced cancer. These findings may inform antibiotic decision-making among palliative care providers.
Sections du résumé
BACKGROUND
Older adults with advanced cancer are exposed to antibiotics but estimates of adverse drug events associated with antibiotic therapy are lacking.
AIM
Evaluate the association of antibiotic therapy with adverse drug events in older adults with advanced cancer.
DESIGN
Cohort study where the exposure was the ratio of days of therapy of an oral or intravenous antibiotic per patient-day and the outcome was an adverse drug event, defined as cardiotoxicity, hepatotoxicity, nephrotoxicity,
SETTING/PARTICIPANTS
Patients aged ⩾65 years with solid tumors from a tertiary care center who received palliative chemotherapy (
RESULTS
Mean age was 75 ± 6.6 years, and 52% were female. Common tumors were lung (31%,
CONCLUSION
Antibiotic therapy was independently associated with adverse drug events in hospitalized older adults with advanced cancer. These findings may inform antibiotic decision-making among palliative care providers.
Identifiants
pubmed: 36999898
doi: 10.1177/02692163231162889
doi:
Substances chimiques
Anti-Bacterial Agents
0
Cephalosporins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
793-798Subventions
Organisme : NIA NIH HHS
ID : P30 AG021342
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007517
Pays : United States