Effects of deep brain stimulation frequency on eye movements and cognitive control.
Journal
NPJ Parkinson's disease
ISSN: 2373-8057
Titre abrégé: NPJ Parkinsons Dis
Pays: United States
ID NLM: 101675390
Informations de publication
Date de publication:
31 Mar 2023
31 Mar 2023
Historique:
received:
28
06
2022
accepted:
06
02
2023
medline:
1
4
2023
entrez:
31
3
2023
pubmed:
1
4
2023
Statut:
epublish
Résumé
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for Parkinson's disease (PD). Varying the frequency DBS has differential effects on axial and distal limb functions, suggesting differing modulation of relevant pathways. The STN is also a critical node in oculomotor and associative networks, but the effect of stimulation frequency on these networks remains unknown. This study aimed to investigate the effects of 80 hz vs. 130 Hz frequency STN-DBS on eye movements and executive control. Twenty-one STN-DBS PD patients receiving 130 Hz vs. 80 Hz stimulation were compared to a healthy control group (n = 16). All participants were tested twice in a double-blind manner. We examined prosaccades (latency and gain) and antisaccades (latency of correct and incorrect antisaccades, error rate and gain of the correct antisaccades). Executive function was tested with the Stroop task. The motor condition was assessed using Unified Parkinson's Disease Rating Scale part III. The antisaccadic error rate was higher in patients (p = 0.0113), more so in patients on 80 Hz compared to 130 Hz (p = 0.001) stimulation. The differences between patients and controls and between frequencies for all other eye-movements or cognitive measures were not statistically significant. We show that 80 Hz STN-DBS in PD reduces the ability to maintain stable fixation but does not alter inhibition, resulting in a higher antisaccade error rate presumably due to less efficient fixation, without altering the motor state. This provides a wider range of stimulation parameters that can reduce specific DBS-related effects without affecting motor outcomes.
Identifiants
pubmed: 37002261
doi: 10.1038/s41531-023-00470-8
pii: 10.1038/s41531-023-00470-8
pmc: PMC10066205
doi:
Types de publication
Journal Article
Langues
eng
Pagination
50Subventions
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation)
ID : P2GEP3-151597
Informations de copyright
© 2023. The Author(s).
Références
Science. 2007 Nov 23;318(5854):1309-12
pubmed: 17962524
Mov Disord. 2014 Feb;29(2):270-4
pubmed: 24449169
Brain. 2000 Jun;123 ( Pt 6):1142-54
pubmed: 10825353
Clin Neurophysiol. 2018 Nov;129(11):2421-2432
pubmed: 30292079
Lancet. 1995 Jan 14;345(8942):91-5
pubmed: 7815888
J Neurol. 2001 Jul;248(7):603-11
pubmed: 11518003
Exp Brain Res. 2016 Apr;234(4):1133-43
pubmed: 26758720
Arch Clin Neuropsychol. 2010 Mar;25(2):146-52
pubmed: 20139109
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Ann Neurol. 1994 Apr;35(4):420-6
pubmed: 8154868
Ann Neurol. 2009 Dec;66(6):817-24
pubmed: 20035509
Mov Disord. 2015 Feb;30(2):128-40
pubmed: 25297382
J Neurol Neurosurg Psychiatry. 2011 Apr;82(4):358-63
pubmed: 20571041
Neurology. 2017 Feb 28;88(9):853-861
pubmed: 28130466
Nat Rev Neurosci. 2004 Mar;5(3):218-28
pubmed: 14976521
Prog Brain Res. 2019;249:297-305
pubmed: 31325988
J Neurosci. 2013 Apr 17;33(16):6895-904
pubmed: 23595748
J Neuroeng Rehabil. 2013 Apr 03;10:33
pubmed: 23551890
Neuromodulation. 2010 Jan;13(1):17-25
pubmed: 21992760
J Neurol Neurosurg Psychiatry. 2000 Mar;68(3):381-4
pubmed: 10675227
Exp Brain Res. 2012 Jan;216(2):169-79
pubmed: 22057780
J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):989-994
pubmed: 29654112
Mov Disord. 2018 Jan;33(1):169-173
pubmed: 29266392
Front Syst Neurosci. 2013 Dec 25;7:118
pubmed: 24399941
J Clin Exp Neuropsychol. 2016 Sep;38(7):745-51
pubmed: 27133973
Neurology. 2000 Dec 12;55(11):1621-6
pubmed: 11113214
J Parkinsons Dis. 2015;5(2):321-31
pubmed: 25720447
Cogn Psychol. 2000 Aug;41(1):49-100
pubmed: 10945922
Lancet Neurol. 2013 Jan;12(1):37-44
pubmed: 23168021
Lancet Neurol. 2010 Jun;9(6):581-91
pubmed: 20434403
PLoS One. 2012;7(3):e32830
pubmed: 22427894
Mov Disord. 2011 Mar;26(4):659-63
pubmed: 21506146
Exp Brain Res. 1999 Nov;129(1):38-48
pubmed: 10550501
Brain. 2004 Mar;127(Pt 3):460-77
pubmed: 14607787
Front Behav Neurosci. 2016 May 03;10:85
pubmed: 27199693
Ann Neurol. 2005 Jul;58(1):168; author reply 168-9
pubmed: 15984018
J Neurosci. 2015 Sep 23;35(38):13043-52
pubmed: 26400935
Neuropsychologia. 2011 Jun;49(7):1794-806
pubmed: 21420990
J Neurosurg. 2005 Dec;103(6):956-67
pubmed: 16381181
Neurology. 2003 Jan 14;60(1):78-81
pubmed: 12525722
J Clin Neurosci. 2012 Aug;19(8):1119-24
pubmed: 22705130
Neurol Neurochir Pol. 2017 Sep - Oct;51(5):354-360
pubmed: 28669542
Neurology. 2000;55(12 Suppl 6):S40-4
pubmed: 11188974
Exp Neurol. 2009 Apr;216(2):481-9
pubmed: 19320006
BMC Neurol. 2012 Feb 29;12:5
pubmed: 22375860
Brain Stimul. 2012 Jul;5(3):388-392
pubmed: 21824834
Curr Biol. 2008 May 20;18(10):R412-R414
pubmed: 18492468
Arch Neurol. 2006 Sep;63(9):1273-6
pubmed: 16966504
Curr Opin Neurol. 2016 Feb;29(1):69-73
pubmed: 26641812
Front Neurol. 2018 Jun 12;9:444
pubmed: 29946295
Eur J Neurosci. 2021 Apr;53(7):2344-2361
pubmed: 32643303
Clin Neurophysiol. 2008 Aug;119(8):1857-1863
pubmed: 18567536
Exp Brain Res. 2016 Jul;234(7):1837-1848
pubmed: 26892884
J Parkinsons Dis. 2019;9(1):141-151
pubmed: 30594934
Mov Disord. 2007 Sep 15;22(12):1810-3
pubmed: 17887119
J Parkinsons Dis. 2018;8(2):267-271
pubmed: 29614696
Curr Opin Neurol. 2004 Feb;17(1):17-25
pubmed: 15090873
Clin Neuropsychol. 2004 May;18(2):284-302
pubmed: 15587675
Exp Brain Res. 2017 Feb;235(2):615-626
pubmed: 27844097
Mov Disord. 2002;17 Suppl 3:S188-97
pubmed: 11948776
Exp Brain Res. 2005 Apr;162(3):357-65
pubmed: 15599721
Mov Disord. 2015 May;30(6):843-7
pubmed: 25600361
J Neuropsychol. 2013 Sep;7(2):193-224
pubmed: 24007368
Neurology. 2010 Mar 2;74(9):743-8
pubmed: 20194913
Nat Rev Neurosci. 2015 Dec;16(12):719-32
pubmed: 26530468
Neurology. 2008 Jul 8;71(2):80-4
pubmed: 18420482