Peptides for trans-blood-brain barrier delivery.

Blood-Brain Barrier Radiopharmaceuticals Drug Delivery Systems Biological Transport Cell-Penetrating Peptides / chemistry
blood-brain barrier cell penetrating peptides peptides radiopharmaceuticals

Journal

Journal of labelled compounds & radiopharmaceuticals
ISSN: 1099-1344
Titre abrégé: J Labelled Comp Radiopharm
Pays: England
ID NLM: 7610510

Informations de publication

Date de publication:
07 2023
Historique:
revised: 02 03 2023
received: 06 10 2022
accepted: 29 03 2023
medline: 23 10 2023
pubmed: 2 4 2023
entrez: 1 4 2023
Statut: ppublish

Résumé

Trans-blood-brain barrier (BBB) delivery of therapeutic and diagnostic agents is a major challenge in the development of central nervous system (CNS) targeted radiopharmaceuticals. This review is an introduction to the use of peptides as delivery agents to transport cargos into the CNS. The most widely used BBB-penetrating peptides are reviewed here, with a particular emphasis on the broad range of cargos delivered into the CNS using these. Cell-penetrating peptides (CPPs) have been deployed as trans-BBB delivery agents for some time; new developments in the CPP field offer exciting opportunities for the design of next generation trans-BBB complexes. Many of the peptides highlighted here are ready to be combined with diagnostic and therapeutic radiopharmaceuticals to develop highly effective CNS-targeted agents.

Identifiants

DOI: 10.1002/jlcr.4023 PMID: 37002811
pubmed: 37002811
doi: 10.1002/jlcr.4023
doi:

Substances chimiques

Radiopharmaceuticals 0
Cell-Penetrating Peptides 0

Types de publication

Review Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

237-248

Informations de copyright

© 2023 The Authors. Journal of Labelled Compounds and Radiopharmaceuticals published by John Wiley & Sons Ltd.

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Auteurs

Reuben Blades (R)

Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.

Lars M Ittner (LM)

Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.

Ole Tietz (O)

Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
ORCID: 0000-0001-8781-256X

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › Peptides for trans-blood-brain barrier delivery.
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › Peptides for trans-blood-brain barrier delivery.
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Peptides for trans-blood-brain barrier delivery.
questionsmedicales.fr › Métabolisme › Transport biologique › Peptides for trans-blood-brain barrier delivery.
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides de pénétration cellulaire › Peptides for trans-blood-brain barrier delivery.