Inhibition of Tumor Metastasis by Liquid-Nitrogen-Shocked Tumor Cells with Oncolytic Viruses Infection.
cancer immunotherapy
cell delivery
drug delivery
metastasis treatment
oncolytic virotherapy
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
revised:
27
03
2023
received:
28
12
2022
medline:
17
7
2023
pubmed:
2
4
2023
entrez:
1
4
2023
Statut:
ppublish
Résumé
Despite the superior tumor lytic efficacy of oncolytic viruses (OVs), their systemic delivery still faces the challenges of limited circulating periods, poor tumor tropism, and spontaneous antiviral immune responses. Herein, a virus-concealed tumor-targeting strategy enabling OVs' delivery toward lung metastasis via systemic administration is described. The OVs can actively infect, be internalized, and cloak into tumor cells. Then the tumor cells are subsequently treated with liquid-nitrogen-shocking to eliminate the pathogenicity. Such a Trojan Horse-like vehicle avoids virus neutralization and clearance in the bloodstream and facilitates tumor-targeted delivery for more than 110-fold virus enrichment in the tumor metastasis. In addition, this strategy can serve as a tumor vaccine and initiate endogenous adaptive antitumor effects through increasing the memory T cells and modulating the tumor immune microenvironment, including reducing the M2 macrophage, downregulating Treg cells, and priming T cells.
Identifiants
pubmed: 37002917
doi: 10.1002/adma.202212210
doi:
Substances chimiques
Cancer Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2212210Subventions
Organisme : National Key R&D Program of China
ID : 2021YFA0909900
Organisme : National Natural Science Foundation of China
ID : 52173142
Organisme : National Natural Science Foundation of China
ID : 52233013
Organisme : Startup Package of Zhejiang University
Informations de copyright
© 2023 Wiley-VCH GmbH.
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