Effects of food, fasting, and exercise on plasma pyrophosphate levels and ENPP1 activity in healthy adults.

Autosomal recessive hypophosphatemic rickets type 2 Biomarker Calcification Ectonucleotide pyrophosphatase/phosphodiesterase 1 Generalized arterial calcification of infancy Inorganic pyrophosphate

Journal

Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048

Informations de publication

Date de publication:
06 2023
Historique:
received: 30 08 2022
revised: 21 03 2023
accepted: 23 03 2023
medline: 24 4 2023
pubmed: 2 4 2023
entrez: 1 4 2023
Statut: ppublish

Résumé

Inorganic pyrophosphate (PP In this single-center trial, a clinical laboratory improvement amendment (CLIA) validated modified sulfurylase-based adenosine 5-triphosphate (ATP) assay was used to measure PP There is a circadian increase in mean PP Plasma levels of PP

Sections du résumé

BACKGROUND
Inorganic pyrophosphate (PP
METHODS
In this single-center trial, a clinical laboratory improvement amendment (CLIA) validated modified sulfurylase-based adenosine 5-triphosphate (ATP) assay was used to measure PP
RESULTS
There is a circadian increase in mean PP
CONCLUSION
Plasma levels of PP

Identifiants

pubmed: 37003563
pii: S8756-3282(23)00083-2
doi: 10.1016/j.bone.2023.116750
pii:
doi:

Substances chimiques

Adenosine Triphosphate 8L70Q75FXE
Diphosphates 0
diphosphoric acid 4E862E7GRQ
Phosphoric Diester Hydrolases EC 3.1.4.-
Pyrophosphatases EC 3.6.1.-
ectonucleotide pyrophosphatase phosphodiesterase 1 EC 3.1.4.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

116750

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Gus Khursigara (G)

Inozyme Pharma, 321 Summer St, Suite 400, Boston, MA 02201, United States of America. Electronic address: gus.khursigara@inozyme.com.

Pedro Huertas (P)

Inozyme Pharma, 321 Summer St, Suite 400, Boston, MA 02201, United States of America.

Deborah Wenkert (D)

Inozyme Pharma, 321 Summer St, Suite 400, Boston, MA 02201, United States of America.

Kevin O'Brien (K)

Inozyme Pharma, 321 Summer St, Suite 400, Boston, MA 02201, United States of America.

Yves Sabbagh (Y)

Inozyme Pharma, 321 Summer St, Suite 400, Boston, MA 02201, United States of America.

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Classifications MeSH