Sigma 1 receptor activation improves retinal structure and function in the Rho

Animals Female Male Mice Color Vision Disease Models, Animal Electroretinography Retina / pathology Retinal Degeneration / pathology Retinitis Pigmentosa / pathology Rhodopsin rho GTP-Binding Proteins / metabolism Sigma-1 Receptor
(+)-pentazocine Photoreceptor cells Retinal degeneration Rhodopsin P23H Visual acuity

Journal

Experimental eye research
ISSN: 1096-0007
Titre abrégé: Exp Eye Res
Pays: England
ID NLM: 0370707

Informations de publication

Date de publication:
05 2023
Historique:
received: 12 12 2022
revised: 17 03 2023
accepted: 27 03 2023
pmc-release: 01 05 2024
medline: 28 4 2023
pubmed: 2 4 2023
entrez: 1 4 2023
Statut: ppublish

Résumé

Retinitis pigmentosa (RP) is a group of devastating inherited retinal diseases that leads to visual impairment and oftentimes complete blindness. Currently no cure exists for RP thus research into prolonging vision is imperative. Sigma 1 receptor (Sig1R) is a promising small molecule target that has neuroprotective benefits in retinas of rapidly-degenerating mouse models. It is not clear whether Sig1R activation can provide similar neuroprotective benefits in more slowly-progressing RP models. Here, we examined Sig1R-mediated effects in the slowly-progressing Rho

Identifiants

DOI: 10.1016/j.exer.2023.109462 PMID: 37003581 PMC: PMC10155485
pubmed: 37003581
pii: S0014-4835(23)00083-0
doi: 10.1016/j.exer.2023.109462
pmc: PMC10155485
mid: NIHMS1891414
pii:
doi:

Substances chimiques

Rhodopsin 9009-81-8
rho GTP-Binding Proteins EC 3.6.5.2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109462

Subventions

Organisme : NEI NIH HHS
ID : P30 EY031631
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY012830
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY028103
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

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Auteurs

Shannon R Barwick (SR)

Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA. Electronic address: sbarwick@augusta.edu.

Haiyan Xiao (H)

Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA.

David Wolff (D)

Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA.

Jing Wang (J)

Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA.

Elizabeth Perry (E)

Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA.

Brendan Marshall (B)

Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA.

Sylvia B Smith (SB)

Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA; Department of Ophthalmology, Medical College of Georgia, Augusta University, Augusta, GA, USA.

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Classifications MeSH

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questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Sigma 1 receptor activation improves retinal...
questionsmedicales.fr › Phénomènes physiologiques oculaires › Vision › Vision des couleurs › Sigma 1 receptor activation improves retinal...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Sigma 1 receptor activation improves retinal...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Électrodiagnostic › Électrorétinographie › Sigma 1 receptor activation improves retinal...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Sigma 1 receptor activation improves retinal...
questionsmedicales.fr › Maladies de l'oeil › Rétinopathies › Dégénérescence de la rétine › Sigma 1 receptor activation improves retinal...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Maladies héréditaires de l'oeil › Rétinite pigmentaire › Sigma 1 receptor activation improves retinal...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Pigments rétiniens › Opsines › Opsines des bâtonnets › Rhodopsine › Sigma 1 receptor activation improves retinal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rho › Sigma 1 receptor activation improves retinal...