Intestinal barrier functions in hematologic and oncologic diseases.
Complications
Hematologic
Intestinal barrier
Oncologic
Pathogenesis
Journal
Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741
Informations de publication
Date de publication:
31 03 2023
31 03 2023
Historique:
received:
15
03
2023
accepted:
26
03
2023
medline:
4
4
2023
entrez:
2
4
2023
pubmed:
3
4
2023
Statut:
epublish
Résumé
The intestinal barrier is a complex structure that not only regulates the influx of luminal contents into the systemic circulation but is also involved in immune, microbial, and metabolic homeostasis. Evidence implicating disruption in intestinal barrier functions in the development of many systemic diseases, ranging from non-alcoholic steatohepatitis to autism, or systemic complications of intestinal disorders has increased rapidly in recent years, raising the possibility of the intestinal barrier as a potential target for therapeutic intervention to alter the course and mitigate the complications associated with these diseases. In addition to the disease process being associated with a breach in the intestinal barrier functions, patients with hematologic and oncologic diseases are particularly at high risks for the development of increased intestinal permeability, due to the frequent use of broad-spectrum antibiotics and chemoradiation. They also face a distinct challenge of being intermittently severely neutropenic due to treatment of the underlying conditions. In this review, we will discuss how hematologic and oncologic diseases are associated with disruption in the intestinal barrier and highlight the complications associated with an increase in the intestinal permeability. We will explore methods to modulate the complication. To provide a background for our discussion, we will first examine the structure and appraise the methods of evaluation of the intestinal barrier.
Identifiants
pubmed: 37004099
doi: 10.1186/s12967-023-04091-w
pii: 10.1186/s12967-023-04091-w
pmc: PMC10064590
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
233Informations de copyright
© 2023. The Author(s).
Références
J Transl Med. 2021 Sep 20;19(1):397
pubmed: 34544432
Nat Med. 2006 Dec;12(12):1365-71
pubmed: 17115046
Am J Clin Nutr. 2009 Sep;90(3):587-94
pubmed: 19587086
Lancet Infect Dis. 2006 Apr;6(4):226-33
pubmed: 16554247
FASEB J. 2002 Nov;16(13):1835-7
pubmed: 12354695
JAMA. 2020 Jan 7;323(1):19-20
pubmed: 31825458
Biol Blood Marrow Transplant. 2014 Oct;20(10):1626-33
pubmed: 24973628
J Surg Res. 2004 Jan;116(1):14-8
pubmed: 14732344
F1000Res. 2015 Jul 13;4:231
pubmed: 27239268
J Clin Invest. 2012 Jan;122(1):62-9
pubmed: 22156200
PLoS One. 2017 Jun 27;12(6):e0179586
pubmed: 28654658
Biol Blood Marrow Transplant. 2012 Aug;18(8):1295-301
pubmed: 22387347
Surgery. 1996 Aug;120(2):411-6; discussion 416-7
pubmed: 8751612
J Biol Chem. 2005 Jul 29;280(30):27949-59
pubmed: 15923643
Nat Med. 2019 Jul;25(7):1096-1103
pubmed: 31263284
Gut Microbes. 2021 Jan-Dec;13(1):1968257
pubmed: 34494943
Int J Infect Dis. 2015 Oct;39:53-6
pubmed: 26358855
Gastroenterology. 2009 Feb;136(2):551-63
pubmed: 19027740
Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G367-76
pubmed: 14766535
Amino Acids. 2015 Oct;47(10):2143-54
pubmed: 24965526
Cancers (Basel). 2022 Jan 29;14(3):
pubmed: 35158960
Drugs Aging. 1995 Sep;7(3):212-25
pubmed: 8535051
Ann Clin Biochem. 2000 Jul;37 ( Pt 4):512-9
pubmed: 10902869
Int J Parasitol. 2014 Jun;44(7):467-73
pubmed: 24704779
J Transl Med. 2018 Aug 30;16(1):239
pubmed: 30165857
Expert Opin Biol Ther. 2009 Jun;9(6):779-87
pubmed: 19456212
Oncogene. 2012 Aug 9;31(32):3679-95
pubmed: 22139080
Nat Commun. 2022 May 9;13(1):2522
pubmed: 35534496
Br J Haematol. 2022 Feb;196(3):777-780
pubmed: 34632582
PLoS Pathog. 2017 Feb 27;13(2):e1006202
pubmed: 28241080
Int J Mol Sci. 2020 Nov 07;21(21):
pubmed: 33171747
Science. 2002 Mar 1;295(5560):1726-9
pubmed: 11872843
World J Gastrointest Oncol. 2018 Mar 15;10(3):71-81
pubmed: 29564037
Nature. 2018 May;557(7706):580-584
pubmed: 29769727
Therap Adv Gastroenterol. 2012 Nov;5(6):403-20
pubmed: 23152734
BMC Gastroenterol. 2014 Nov 18;14:189
pubmed: 25407511
Am J Physiol. 1997 Oct;273(4):C1378-85
pubmed: 9357784
Am J Physiol Gastrointest Liver Physiol. 2005 Mar;288(3):G422-30
pubmed: 15701621
Eur J Haematol. 1998 Apr;60(4):267-8
pubmed: 9579883
Mol Biol Cell. 2009 Sep;20(17):3930-40
pubmed: 19605556
Surgery. 2003 Oct;134(4):574-80; discussion 580-1
pubmed: 14605617
Nature. 2012 Nov 8;491(7423):254-8
pubmed: 23034650
Cancer Biol Ther. 2008 Jul;7(7):1139-45
pubmed: 18535404
Clin Nutr. 2008 Jun;27(3):328-39
pubmed: 18440672
J Natl Cancer Inst Monogr. 2001;(29):26-30
pubmed: 11694562
Med Princ Pract. 2012;21(1):36-9
pubmed: 22024548
Integr Cancer Ther. 2018 Dec;17(4):1027-1047
pubmed: 30136590
J Clin Med. 2021 Jun 06;10(11):
pubmed: 34204044
Crit Rev Oral Biol Med. 2002;13(5):380-9
pubmed: 12393757
J Inflamm Res. 2020 Oct 14;13:719-735
pubmed: 33116751
JPEN J Parenter Enteral Nutr. 2003 May-Jun;27(3):198-206; discussion 206-7
pubmed: 12757114
Proc Natl Acad Sci U S A. 2010 May 4;107(18):8237-41
pubmed: 20404178
Mediators Inflamm. 2015;2015:628157
pubmed: 26582965
Curr Pharm Des. 2018;24(35):4154-4166
pubmed: 30277149
Dig Dis Sci. 2007 Sep;52(9):2340-5
pubmed: 17415646
Front Immunol. 2017 Oct 02;8:1254
pubmed: 29038658
Gastroenterology. 2001 Sep;121(3):580-91
pubmed: 11522742
Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):265-271
pubmed: 29222265
N Engl J Med. 2018 Jul 19;379(3):226-235
pubmed: 30021096
Am J Physiol Gastrointest Liver Physiol. 2016 Jul 1;311(1):G1-G15
pubmed: 27151941
Tissue Barriers. 2015 Apr 03;3(1-2):e982426
pubmed: 25838985
Gastroenterology. 2010 Aug;139(2):388-92, 392.e1-2
pubmed: 20561523
Mol Biol Cell. 2013 Oct;24(19):3056-68
pubmed: 23924897
Am J Physiol Gastrointest Liver Physiol. 2017 Jun 1;312(6):G559-G571
pubmed: 28336545
J Leukoc Biol. 1999 Sep;66(3):411-5
pubmed: 10496310
PLoS Pathog. 2010 Apr 08;6(4):e1000852
pubmed: 20386714
J Cell Biol. 2010 Apr 5;189(1):111-26
pubmed: 20351069
Expert Rev Gastroenterol Hepatol. 2017 Sep;11(9):821-834
pubmed: 28650209
Cancer Gene Ther. 2022 Aug;29(8-9):1080-1096
pubmed: 34987176
Cancer Biol Ther. 2014 Feb;15(2):236-44
pubmed: 24316664
Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):
pubmed: 33876770
Int Rev Immunol. 2017 Mar 4;36(2):57-73
pubmed: 28060562
Vet Surg. 2000 Jan-Feb;29(1):17-27
pubmed: 10653491
Am J Physiol Gastrointest Liver Physiol. 2020 May 1;318(5):G966-G979
pubmed: 32308038
Cancer Chemother Pharmacol. 2016 Oct;78(4):863-74
pubmed: 27590707
Cell Mol Life Sci. 2011 Nov;68(22):3635-41
pubmed: 21947475
Dig Liver Dis. 2004 May;36(5):337-41
pubmed: 15191203
Curr Res Microb Sci. 2021 May 08;2:100036
pubmed: 34841327
J Clin Invest. 2019 Feb 1;129(2):902-914
pubmed: 30667372
Curr Opin Hematol. 2010 Nov;17(6):493-9
pubmed: 20827187
Aliment Pharmacol Ther. 2015 Sep;42(5):515-28
pubmed: 26147207
Nat Rev Gastroenterol Hepatol. 2013 Jun;10(6):352-61
pubmed: 23478383
Am J Hematol. 2018 Aug;93(4):E91-E93
pubmed: 29274089
N Engl J Med. 2020 Feb 27;382(9):822-834
pubmed: 32101664
Cell Mol Gastroenterol Hepatol. 2020;10(2):327-340
pubmed: 32304780
Blood Lymphat Cancer. 2022 Aug 29;12:119-136
pubmed: 36060553
Int J Mol Sci. 2021 Aug 31;22(17):
pubmed: 34502383
Cancer Treat Rev. 2007 Aug;33(5):448-60
pubmed: 17507164
Clin Microbiol Rev. 2013 Jan;26(1):2-18
pubmed: 23297256
Best Pract Res Clin Haematol. 2018 Jun;31(2):135-146
pubmed: 29909914
J Immunol. 2008 Apr 15;180(8):5653-61
pubmed: 18390750
J Transl Med. 2019 May 30;17(1):183
pubmed: 31146745
Eur J Clin Microbiol Infect Dis. 2017 May;36(5):757-769
pubmed: 28063002
Nat Rev Microbiol. 2012 Sep;10(9):655-66
pubmed: 22886237
Clin Microbiol Infect. 2012 Mar;18(3):282-9
pubmed: 21668576
Nature. 2015 Sep 24;525(7570):528-32
pubmed: 26374999
Ann N Y Acad Sci. 2005;1054:40-7
pubmed: 16339650
J Pediatr Gastroenterol Nutr. 2012 Apr;54(4):463-70
pubmed: 22197938
Environ Microbiol. 2017 Jan;19(1):29-41
pubmed: 27928878
Dig Dis Sci. 1992 Sep;37(9):1362-7
pubmed: 1505286
Gut Microbes. 2017 Jul 4;8(4):400-411
pubmed: 28267403
Mol Autism. 2016 Nov 29;7:49
pubmed: 27957319
Clin Infect Dis. 2020 Jan 2;70(2):232-241
pubmed: 30877304
Cell. 2016 Nov 17;167(5):1339-1353.e21
pubmed: 27863247
Vet Pathol. 2015 May;52(3):445-55
pubmed: 25428410
Sci Rep. 2019 Jun 17;9(1):8659
pubmed: 31209247
Emerg Infect Dis. 2021 Aug;27(8):
pubmed: 34287140
Med Mal Infect. 2014 Jan;44(1):1-8
pubmed: 24290962
Lancet. 2000 Apr 29;355(9214):1518-9
pubmed: 10801176
J Biol Chem. 2010 Apr 16;285(16):12037-46
pubmed: 20177070
J Int Med Res. 2019 Mar;47(3):1279-1287
pubmed: 32516018
J Infect Dis. 2019 May 5;219(11):1766-1776
pubmed: 30566600
Cell Microbiol. 2005 Dec;7(12):1782-97
pubmed: 16309464
Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4200-5
pubmed: 20142489
Nutr Clin Pract. 2016 Apr;31(2):171-9
pubmed: 26507188
N Engl J Med. 2019 Nov 21;381(21):2043-2050
pubmed: 31665575
J Leukoc Biol. 2016 Oct;100(4):687-698
pubmed: 27418356
Blood. 2000 Oct 1;96(7):2451-9
pubmed: 11001897
Bone Marrow Transplant. 2008 Sep;42(5):337-43
pubmed: 18560408
J Pediatr. 2004 Nov;145(5):612-6
pubmed: 15520759
Nat Rev Immunol. 2016 Oct;16(10):639-49
pubmed: 27498766
Lancet Infect Dis. 2015 Jan;15(1):95-108
pubmed: 25459220
Clin Microbiol Rev. 2005 Apr;18(2):247-63
pubmed: 15831824
PLoS One. 2021 Aug 25;16(8):e0255956
pubmed: 34432825
Inflamm Bowel Dis. 2019 Jul 17;25(8):1302-1312
pubmed: 30877772
J Gastroenterol. 2005 Oct;40(10):925-31
pubmed: 16261428
Am J Hematol. 2004 Jun;76(2):126-33
pubmed: 15164377
J Diabetes Complications. 2021 Feb;35(2):107766
pubmed: 33168395
Cancer Res. 2019 Jul 15;79(14):3662-3675
pubmed: 31064848
Bone Marrow Transplant. 2016 Feb;51(2):262-6
pubmed: 26569091
Mediators Inflamm. 2021 Oct 12;2021:6259381
pubmed: 34675753
Int J Mol Sci. 2017 May 12;18(5):
pubmed: 28498331
Br J Haematol. 2013 Jul;162(1):3-14
pubmed: 23593937
Mol Biol Cell. 2009 Aug;20(16):3713-24
pubmed: 19535456
BMC Gastroenterol. 2022 Jan 10;22(1):16
pubmed: 35012471
ISRN Gastroenterol. 2011;2011:892971
pubmed: 21991534
Digestion. 2019;100(1):72-78
pubmed: 30332668