Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target.

Humans Animals Toxoplasma / genetics Parasites Toxoplasmosis / drug therapy Coenzyme A Tuberculosis
PanC Pantoate β-alanine ligase Pantothenate Pantothenate synthetase SW314 T. gondii

Journal

International journal for parasitology. Drugs and drug resistance
ISSN: 2211-3207
Titre abrégé: Int J Parasitol Drugs Drug Resist
Pays: Netherlands
ID NLM: 101576715

Informations de publication

Date de publication:
08 2023
Historique:
received: 20 11 2022
revised: 08 03 2023
accepted: 12 03 2023
medline: 31 7 2023
pubmed: 3 4 2023
entrez: 2 4 2023
Statut: ppublish

Résumé

Toxoplasma gondii is a pervasive apicomplexan parasite that can cause severe disease and death in immunocompromised individuals and the developing foetus. The treatment of toxoplasmosis often leads to serious side effects and novel drugs and drug targets are therefore actively sought. In 2014, Mageed and colleagues suggested that the T. gondii pantothenate synthetase, the enzyme responsible for the synthesis of the vitamin B

Identifiants

DOI: 10.1016/j.ijpddr.2023.03.003 PMID: 37004488 PMC: PMC10102396
pubmed: 37004488
pii: S2211-3207(23)00011-8
doi: 10.1016/j.ijpddr.2023.03.003
pmc: PMC10102396
pii:
doi:

Substances chimiques

Coenzyme A SAA04E81UX

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-8

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Vanessa M Howieson (VM)

Research School of Biology, The Australian National University, Canberra, ACT, Australia.

Joy Zeng (J)

Research School of Biology, The Australian National University, Canberra, ACT, Australia.

Joachim Kloehn (J)

Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Christina Spry (C)

Research School of Biology, The Australian National University, Canberra, ACT, Australia.

Chiara Marchetti (C)

Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

Matteo Lunghi (M)

Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Emmanuel Varesio (E)

Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, CMU, Rue Michel-Servet 1, 1211, Geneva, Switzerland; Mass Spectrometry Core Facility (MZ 2.0), University of Geneva, Geneva, 1211, Switzerland.

Andrew Soper (A)

Research School of Biology, The Australian National University, Canberra, ACT, Australia.

Anthony G Coyne (AG)

Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

Chris Abell (C)

Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

Giel G van Dooren (GG)

Research School of Biology, The Australian National University, Canberra, ACT, Australia. Electronic address: giel.vandooren@anu.edu.au.

Kevin J Saliba (KJ)

Research School of Biology, The Australian National University, Canberra, ACT, Australia. Electronic address: kevin.saliba@anu.edu.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pantothenate biosynthesis in Toxoplasma gondii...
questionsmedicales.fr › Eucaryotes › Animaux › Pantothenate biosynthesis in Toxoplasma gondii...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Coccidia › Eimeriida › Sarcocystidae › Toxoplasma › Pantothenate biosynthesis in Toxoplasma gondii...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Parasites › Pantothenate biosynthesis in Toxoplasma gondii...
questionsmedicales.fr › Infection › Maladies parasitaires › Protozooses › Coccidiose › Toxoplasmose › Pantothenate biosynthesis in Toxoplasma gondii...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Coenzyme A › Pantothenate biosynthesis in Toxoplasma gondii...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › Pantothenate biosynthesis in Toxoplasma gondii...