Characterization of Phietavirus Henu 2 in the virome of individuals with acute gastroenteritis.
Biotechnology
Gastroenteritis
Methicillin-resistant
Phage
Phietavirus
Staphylococcus aureus
Journal
Virus genes
ISSN: 1572-994X
Titre abrégé: Virus Genes
Pays: United States
ID NLM: 8803967
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
17
11
2022
accepted:
15
03
2023
medline:
22
5
2023
pubmed:
3
4
2023
entrez:
2
4
2023
Statut:
ppublish
Résumé
There is a growing interest in phages as potential biotechnological tools in human health owing to the antibacterial activity of these viruses. In this study, we characterized a new member (named PhiV_005_BRA/2016) of the recently identified phage species Phietavirus Henu 2. PhiV_005_BRA/2016 was detected through metagenomic analysis of stool samples of individuals with acute gastroenteritis. PhiV_005_BRA/2016 contains double-stranded linear DNA (dsDNA), it has a genome of 43,513 base pairs (bp), with a high identity score (99%) with phage of the genus Phietavirus, species of Phietavirus Henu 2. Life style prediction indicated that PhiV_005_BRA/2016 is a lysogenic phage whose the main host is methicillin-resistant Staphylococcus aureus (MRSA). Indeed, we found PhiV_005_BRA/2016 partially integrated in the genome of distinct MRSA strains. Our findings highlights the importance of large-scale screening of bacteriophages to better understand the emergence of multi-drug resistant bacterial.
Identifiants
pubmed: 37004601
doi: 10.1007/s11262-023-01990-4
pii: 10.1007/s11262-023-01990-4
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
464-472Subventions
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 302677/2019-4
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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