The risk of hypogonadism after testicular sperm extraction in men with various types of azoospermia: a prospective cohort study.
Hypogonadism
Klinefelter syndrome
Non-obstructive azoospermia
Obstructive azoospermia
Testicular sperm extraction
Testosterone
Journal
Reproductive biomedicine online
ISSN: 1472-6491
Titre abrégé: Reprod Biomed Online
Pays: Netherlands
ID NLM: 101122473
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
21
10
2022
revised:
02
01
2023
accepted:
03
02
2023
medline:
5
6
2023
pubmed:
3
4
2023
entrez:
2
4
2023
Statut:
ppublish
Résumé
What is the risk of hypogonadism in men with obstructive azoospermia, non-obstructive azoospermia (NOA) or Klinefelter syndrome after testicular sperm extraction (TESE)? This prospective longitudinal cohort study was carried out between 2007 and 2015. Around 36% of men with Klinefelter syndrome, 4% of men with obstructive azoospermia and 3% of men with NOA needed testosterone replacement therapy (TRT). Klinefelter syndrome was strongly associated with TRT while no association was found between obstructive azoospermia or NOA and TRT. Irrespective of the pre-operative diagnosis, a higher testosterone concentration before TESE was associated with a lower chance of needing TRT. Men with obstructive azoospermia or NOA have a similar moderate risk of clinical hypogonadism after TESE, while this risk is much larger for men with Klinefelter syndrome. The risk of clinical hypogonadism is lower when testosterone concentrations are high before TESE.
Identifiants
pubmed: 37005152
pii: S1472-6483(23)00108-6
doi: 10.1016/j.rbmo.2023.02.003
pii:
doi:
Substances chimiques
Testosterone
3XMK78S47O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
973-981Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.