The Role of Glutathione in Prevention of COVID-19 Immunothrombosis: A Review.
COVID-19
GSH
HIV
SARS-CoV-2
diabetes
glutathione
immunothrombosis
microclot
thrombosis
Journal
Frontiers in bioscience (Landmark edition)
ISSN: 2768-6698
Titre abrégé: Front Biosci (Landmark Ed)
Pays: Singapore
ID NLM: 101612996
Informations de publication
Date de publication:
20 03 2023
20 03 2023
Historique:
received:
13
02
2023
revised:
15
03
2023
accepted:
15
03
2023
medline:
4
4
2023
entrez:
3
4
2023
pubmed:
4
4
2023
Statut:
ppublish
Résumé
Immunothrombosis has emerged as a dominant pathological process exacerbating morbidity and mortality in acute- and long-COVID-19 infections. The hypercoagulable state is due in part to immune system dysregulation, inflammation and endothelial cell damage, as well as a reduction in defense systems. One defense mechanism in particular is glutathione (GSH), a ubiquitously found antioxidant. Evidence suggests that reduction in GSH increases viral replication, pro-inflammatory cytokine release, and thrombosis, as well as decreases macrophage-mediated fibrin removal. The collection of adverse effects as a result of GSH depletion in states like COVID-19 suggest that GSH depletion is a dominant mechanism of immunothrombosis cascade. We aim to review the current literature on the influence of GSH on COVID-19 immunothrombosis pathogenesis, as well as the beneficial effects of GSH as a novel therapeutic for acute- and long-COVID-19.
Identifiants
pubmed: 37005767
pii: S2768-6701(23)00838-9
doi: 10.31083/j.fbl2803059
pmc: PMC10406467
mid: NIHMS1919706
doi:
Substances chimiques
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
59Subventions
Organisme : NHLBI NIH HHS
ID : R15 HL143545
Pays : United States
Informations de copyright
© 2023 The Author(s). Published by IMR Press.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest. VV is serving as one of the Guest editors of this journal. We declare that VV had no involvement in the peer review of this article and has no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to ESH.
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