Implications of quantitative susceptibility mapping at 7 Tesla MRI for microbleeds detection in cerebral small vessel disease.
7 Tesla MRI
cerebral amyloid angiopathy (CAA)
cerebral small vessel disease (CSVD)
hypertensive arteriopathy (HA)
microbleeds
quantitative susceptibility mapping (QSM)
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2023
2023
Historique:
received:
30
11
2022
accepted:
20
02
2023
medline:
4
4
2023
entrez:
3
4
2023
pubmed:
4
4
2023
Statut:
epublish
Résumé
Cerebral microbleeds (MBs) are a hallmark of cerebral small vessel disease (CSVD) and can be found on T2 We explored the implications of using QSM at submillimeter resolution for MBs detection in CSVD. Both 3 and 7 Tesla (T) MRI were performed in elderly participants without MBs and patients with CSVD. MBs were quantified on T2 48 participants [mean age (SD) 70.9 (8.8) years, 48% females] were included: 31 were healthy controls, 6 probable cerebral amyloid angiopathy (CAA), 9 mixed CSVD, and 2 were hypertensive arteriopathy [HA] patients. After accounting for the higher number of MBs detected at 7T QSM (Median = Mdn; Mdn Our observations suggest that QSM at submillimeter resolution improves the detection of MBs in the elderly human brain. A higher prevalence of MBs than so far known in healthy elderly was revealed.
Sections du résumé
Background
UNASSIGNED
Cerebral microbleeds (MBs) are a hallmark of cerebral small vessel disease (CSVD) and can be found on T2
Aims
UNASSIGNED
We explored the implications of using QSM at submillimeter resolution for MBs detection in CSVD.
Methods
UNASSIGNED
Both 3 and 7 Tesla (T) MRI were performed in elderly participants without MBs and patients with CSVD. MBs were quantified on T2
Results
UNASSIGNED
48 participants [mean age (SD) 70.9 (8.8) years, 48% females] were included: 31 were healthy controls, 6 probable cerebral amyloid angiopathy (CAA), 9 mixed CSVD, and 2 were hypertensive arteriopathy [HA] patients. After accounting for the higher number of MBs detected at 7T QSM (Median = Mdn; Mdn
Conclusions
UNASSIGNED
Our observations suggest that QSM at submillimeter resolution improves the detection of MBs in the elderly human brain. A higher prevalence of MBs than so far known in healthy elderly was revealed.
Identifiants
pubmed: 37006483
doi: 10.3389/fneur.2023.1112312
pmc: PMC10050564
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1112312Informations de copyright
Copyright © 2023 Perosa, Rotta, Yakupov, Kuijf, Schreiber, Oltmer, Mattern, Heinze, Düzel and Schreiber.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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