Canakinumab leads to rapid reduction of neutrophilic inflammation and long-lasting response in Schnitzler syndrome.
Canakinumab
Schnitzler syndrome
autoinflammatory disorders
immunohistochemical
neutrophilic inflammation
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2023
2023
Historique:
received:
21
09
2022
accepted:
22
02
2023
medline:
4
4
2023
entrez:
3
4
2023
pubmed:
4
4
2023
Statut:
epublish
Résumé
Interleukin-1 (IL-1)-blocking therapies are effective in reducing disease severity and inflammation in Schnitzler syndrome. Here, we present a patient with Schnitzler syndrome treated successfully using canakinumab for over 10 years. Complete clinical response was associated with a decrease in dermal neutrophil number and expression of the pro-inflammatory cytokines IL-1β, IL-8, and IL-17 as assessed by immunohistochemical studies.
Identifiants
pubmed: 37007766
doi: 10.3389/fmed.2023.1050230
pmc: PMC10050468
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1050230Informations de copyright
Copyright © 2023 Bossart, Seyed Jafari, Heidemeyer, Yan, Feldmeyer, Borradori and Yawalkar.
Déclaration de conflit d'intérêts
NY has served as a consultant for Novartis. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Curr Rheumatol Rep. 2017 Aug;19(8):46
pubmed: 28718061
Expert Rev Clin Immunol. 2010 Nov;6(6):831-41
pubmed: 20979548
Blood. 2003 Nov 15;102(10):3759-64
pubmed: 12881316
Arthritis Res Ther. 2015 Jul 22;17:187
pubmed: 26198339
Front Immunol. 2019 Mar 22;10:546
pubmed: 30967871
MAbs. 2010 Jan-Feb;2(1):3-13
pubmed: 20065636
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Br J Pharmacol. 2020 Aug;177(16):3635-3645
pubmed: 32441764
Acta Haematol. 2008;120(1):1-4
pubmed: 18612198
J Allergy Clin Immunol. 2020 Jun;145(6):1681-1686.e5
pubmed: 31940469
J Allergy Clin Immunol. 2015 Feb;135(2):561-4
pubmed: 25239704