Roles of Ependymal Cells in the Physiology and Pathology of the Central Nervous System.
CNS development
CNS disease
Ependymal cells
central nervous system
Journal
Aging and disease
ISSN: 2152-5250
Titre abrégé: Aging Dis
Pays: United States
ID NLM: 101540533
Informations de publication
Date de publication:
01 Apr 2023
01 Apr 2023
Historique:
received:
20
06
2022
accepted:
26
08
2022
medline:
4
4
2023
entrez:
3
4
2023
pubmed:
4
4
2023
Statut:
epublish
Résumé
Ependymal cells are indispensable components of the central nervous system (CNS). They originate from neuroepithelial cells of the neural plate and show heterogeneity, with at least three types that are localized in different locations of the CNS. As glial cells in the CNS, accumulating evidence demonstrates that ependymal cells play key roles in mammalian CNS development and normal physiological processes by controlling the production and flow of cerebrospinal fluid (CSF), brain metabolism, and waste clearance. Ependymal cells have been attached to great importance by neuroscientists because of their potential to participate in CNS disease progression. Recent studies have demonstrated that ependymal cells participate in the development and progression of various neurological diseases, such as spinal cord injury and hydrocephalus, raising the possibility that they may serve as a potential therapeutic target for the disease. This review focuses on the function of ependymal cells in the developmental CNS as well as in the CNS after injury and discusses the underlying mechanisms of controlling the functions of ependymal cells.
Identifiants
pubmed: 37008045
doi: 10.14336/AD.2022.0826-1
pii: ad-14-2-468
pmc: PMC10017161
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
468-483Informations de copyright
copyright: © 2022 Deng et al.
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