Epidemiology of amyotrophic lateral sclerosis in the north east Tuscany in the 2018-2021 period.
ALS prevalence
Amyotrophic lateral sclerosis
COVID-19
Incidence study
Pandemic
Journal
eNeurologicalSci
ISSN: 2405-6502
Titre abrégé: eNeurologicalSci
Pays: Netherlands
ID NLM: 101667077
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
15
12
2022
revised:
14
02
2023
accepted:
14
03
2023
medline:
4
4
2023
entrez:
3
4
2023
pubmed:
4
4
2023
Statut:
epublish
Résumé
The incidence of Amyotrophic Lateral Sclerosis (ALS) varies among different geographical areas and seems to increase over time. This study aimed to examine the epidemiologic data of ALS in the north-east Tuscany and compare the results with those of similar surveys. Data from ALS cases diagnosed in Florence and Prato Hospitals were prospectively collected from 1st June 2018 to 31st May 2021. The age- and sex-adjusted incidence rate of ALS in cases per 100,000 population was 2.71 (M/F ratio: 1.21), significantly higher as compared to that reported in the 1967-1976 decade in the same geographical area (0.714). The age- and sex-adjusted incidence rate among resident strangers was similar to that of the general population (2.69). A slightly higher incidence rate (4.36) was observed in the north-east area of Florence province, which includes the Mugello valley. The mean prevalence was of 7.17/100,00. The mean age at diagnosis was 69.7 years, with a peak between 70 and 79 years among men and a smoother age curve among women. ALS epidemiological features in north-east Tuscany are in line with other Italian and European Centers. The dramatic increase of the local disease burden over the last decades probably reflects better ascertainment methods and health system.
Sections du résumé
Background
UNASSIGNED
The incidence of Amyotrophic Lateral Sclerosis (ALS) varies among different geographical areas and seems to increase over time. This study aimed to examine the epidemiologic data of ALS in the north-east Tuscany and compare the results with those of similar surveys.
Methods
UNASSIGNED
Data from ALS cases diagnosed in Florence and Prato Hospitals were prospectively collected from 1st June 2018 to 31st May 2021.
Results
UNASSIGNED
The age- and sex-adjusted incidence rate of ALS in cases per 100,000 population was 2.71 (M/F ratio: 1.21), significantly higher as compared to that reported in the 1967-1976 decade in the same geographical area (0.714). The age- and sex-adjusted incidence rate among resident strangers was similar to that of the general population (2.69). A slightly higher incidence rate (4.36) was observed in the north-east area of Florence province, which includes the Mugello valley. The mean prevalence was of 7.17/100,00. The mean age at diagnosis was 69.7 years, with a peak between 70 and 79 years among men and a smoother age curve among women.
Conclusions
UNASSIGNED
ALS epidemiological features in north-east Tuscany are in line with other Italian and European Centers. The dramatic increase of the local disease burden over the last decades probably reflects better ascertainment methods and health system.
Identifiants
pubmed: 37008534
doi: 10.1016/j.ensci.2023.100457
pii: S2405-6502(23)00015-1
pmc: PMC10063398
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100457Informations de copyright
©2023PublishedbyElsevierB.V.
Déclaration de conflit d'intérêts
The authors have stated explicitly that there are no conflicts of interest in connection with this article.
Références
Amyotroph Lateral Scler Frontotemporal Degener. 2019 Feb;20(1-2):90-99
pubmed: 30430867
Neuroepidemiology. 2017;48(1-2):79-85
pubmed: 28528330
J Neurol. 2013 Feb;260(2):572-9
pubmed: 23052600
Sci Rep. 2021 Mar 18;11(1):6207
pubmed: 33737526
J Neurol Neurosurg Psychiatry. 2008 Jan;79(1):30-2
pubmed: 17634215
JAMA Neurol. 2017 Sep 1;74(9):1097-1104
pubmed: 28692730
J Neurol. 2016 Oct;263(10):1919-26
pubmed: 27372451
Arch Neurol. 2009 Apr;66(4):515-9
pubmed: 19364937
J Neurol. 2021 Aug;268(8):2973-2984
pubmed: 33630135
PLoS One. 2014 Apr 10;9(4):e93932
pubmed: 24722455
Amyotroph Lateral Scler Frontotemporal Degener. 2022 May;23(3-4):236-241
pubmed: 34338107
Amyotroph Lateral Scler Frontotemporal Degener. 2018 Nov;19(7-8):522-527
pubmed: 30265157
Neuroepidemiology. 2021;55(5):342-353
pubmed: 34247168
J Neurol Sci. 2010 Nov 15;298(1-2):78-84
pubmed: 20804988
Curr Opin Neurol. 2019 Oct;32(5):771-776
pubmed: 31361627
Amyotroph Lateral Scler Other Motor Neuron Disord. 2000 Dec;1(5):293-9
pubmed: 11464847
Neuroepidemiology. 2013;41(2):118-30
pubmed: 23860588
Eur J Neurol. 2021 Jan;28(1):81-89
pubmed: 32888367
Chin Med J (Engl). 2021 Sep 2;134(18):2231-2236
pubmed: 34483254
J Neurol. 2019 Apr;266(4):817-825
pubmed: 30805795
Amyotroph Lateral Scler Frontotemporal Degener. 2021 Aug;22(5-6):401-409
pubmed: 33641502
Neurology. 2007 Jan 9;68(2):141-5
pubmed: 17210896
Neurology. 2021 Jan 20;:
pubmed: 33472922
Acta Neurol Scand. 1979 Aug;60(2):112-24
pubmed: 495044
Neurology. 1989 Jun;39(6):768-73
pubmed: 2725869
Neuroepidemiology. 2021;55(3):196-205
pubmed: 33902051
Amyotroph Lateral Scler Frontotemporal Degener. 2020 May;21(3-4):222-227
pubmed: 32301340
Amyotroph Lateral Scler. 2011 Nov;12(6):451-7
pubmed: 21732732
J Neurol. 2012 Aug;259(8):1623-31
pubmed: 22231873
Amyotroph Lateral Scler. 2010 Oct;11(5):439-42
pubmed: 20225930
Gend Med. 2010 Dec;7(6):557-70
pubmed: 21195356