Assessment of toxicity and genotoxic safety profile of novel fisetin ruthenium-p-cymene complex in mice.
Fisetin
Flavonoids
Organometallic complex
Ruthenium-p-cymene
Toxicity study
Journal
Toxicological research
ISSN: 1976-8257
Titre abrégé: Toxicol Res
Pays: Singapore
ID NLM: 101483324
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
23
07
2022
revised:
15
11
2022
accepted:
22
11
2022
pmc-release:
01
04
2024
medline:
4
4
2023
entrez:
3
4
2023
pubmed:
4
4
2023
Statut:
epublish
Résumé
Throughout the last decades flavonoids have been considered as a powerful bioactive molecule. Complexation of these flavonoids with metal ions demonstrated the genesis of unique organometallic complexes which provide improved pharmacological and therapeutic activities. In this research, the fisetin ruthenium-p-cymene complex was synthesized and characterized via different analytical methods like UV-visible spectroscopy, Fourier-transform infrared spectroscopy, mass spectroscopy, and scanning electron microscope. The toxicological profile of the complex was evaluated by acute and sub-acute toxicity. Additionally, the mutagenic and genotoxic activity of the complex was assessed by Ames test, chromosomal aberration test, and micronucleus based assay in Swiss albino mice. The acute oral toxicity study exhibited the LD
Identifiants
pubmed: 37008693
doi: 10.1007/s43188-022-00158-w
pii: 158
pmc: PMC10050516
doi:
Types de publication
Journal Article
Langues
eng
Pagination
213-229Informations de copyright
© The Author(s) under exclusive licence to Korean Society of Toxicology 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
Déclaration de conflit d'intérêts
Conflict of interestThe authors have no relevant financial or non-financial interests to disclose.
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