Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum of
GAD65
Shank3
autism
matrix
mouse model
stereotyped behavior
striatum compartmentation
striosomes
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2023
2023
Historique:
received:
06
01
2023
accepted:
16
02
2023
medline:
4
4
2023
entrez:
3
4
2023
pubmed:
4
4
2023
Statut:
epublish
Résumé
Autism is characterized by atypical social communication and stereotyped behaviors. Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are detected in 1-2% of patients with autism and intellectual disability, but the mechanisms underpinning the symptoms remain largely unknown. Here, we characterized the behavior of
Identifiants
pubmed: 37008785
doi: 10.3389/fnmol.2023.1139118
pmc: PMC10061084
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1139118Informations de copyright
Copyright © 2023 Ferhat, Verpy, Biton, Forget, De Chaumont, Mueller, Le Sourd, Coqueran, Schmitt, Rochefort, Rondi-Reig, Leboucher, Boland, Fin, Deleuze, Boekers, Ey and Bourgeron.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer MY declared a shared affiliation with the author ATF to the handling editor at the time of review.
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