Migration of stem-like CD8 T cells between tissue microenvironments underpins successful anti-tumour immune responses.
CD8 T cells
cancer
immune checkpoint blockade
stem-like
trafficking
Journal
Discovery immunology
ISSN: 2754-2483
Titre abrégé: Discov Immunol
Pays: England
ID NLM: 9918486782306676
Informations de publication
Date de publication:
2023
2023
Historique:
received:
13
12
2022
revised:
18
01
2023
accepted:
17
02
2023
medline:
4
4
2023
entrez:
3
4
2023
pubmed:
4
4
2023
Statut:
epublish
Résumé
The clinical success of immune checkpoint blockade in some patients has transformed treatment approaches in cancer and offers the hope of durable curative responses. Building from studies of chronic infection, the composition of tumour infiltrating lymphocytes and in particular, the spectrum of exhausted CD8 T cells has now been characterized in detail, profiling the phenotype, function, transcriptional regulation and even the epigenetic changes. However, what remains less clear is how intratumoural immune cells interface with populations in the periphery, both in terms of sustaining the response in cancer, but also in establishing systemic memory responses that can provide long-term protection. Here we will succinctly review the current understanding of the anti-tumour response, consider the tissue microenvironments that support key cellular subsets and the extent to which cellular migration between these sites impacts the response.
Identifiants
pubmed: 37008996
doi: 10.1093/discim/kyad004
pii: kyad004
pmc: PMC10052398
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
kyad004Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Immunology.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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