The role of neutrophil extracellular traps in necrotizing enterocolitis.
NEC (necrotizing enterocolitis)
NETs (neutrophil extracellular traps)
intestinal disease
neutrophils
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2023
2023
Historique:
received:
11
12
2022
accepted:
27
02
2023
medline:
4
4
2023
entrez:
3
4
2023
pubmed:
4
4
2023
Statut:
epublish
Résumé
Necrotizing enterocolitis (NEC) continues to be one of the most common causes of mortality and morbidity in preterm infants. Although not fully elucidated, studies suggest that prematurity, formula feeding, imbalanced vascular supply, and altered bacterial colonization play major roles in the pathogenesis of NEC. NEC is characterized by increased cytokine release and leukocyte infiltration. Recent data from preterm infants and animal models of NEC suggest that neutrophil extracellular traps (NETs) are released in intestinal tissue. The contribution of NETs in the pathogenesis and/or prevention/treatment of this disease continues to be controversial. Here, we review the available data on NETs release in NEC in human patients and in different NEC models, highlighting their potential contribution to pathology and resolution of inflammation. Here, we review the available data on NETs release in NEC in human patients and the different NEC models, highlighting their potential contribution to pathology or resolution of inflammation.
Identifiants
pubmed: 37009300
doi: 10.3389/fped.2023.1121193
pmc: PMC10050739
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1121193Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM134973
Pays : United States
Informations de copyright
© 2023 Klinke, Chaaban and Boettcher.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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